Cough: New Pharmacology.
Airway nerves
Antitussive
Cough monitoring
Neuromodulators
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
Historique:
received:
21
03
2019
accepted:
02
04
2019
entrez:
8
7
2019
pubmed:
8
7
2019
medline:
8
5
2020
Statut:
ppublish
Résumé
Chronic coughing has a significant impact on the sufferer's quality of life. Despite this, licensed therapies are currently lacking, and until recently novel efficacious therapies for the treatment of chronic cough have remained elusive. In recent years, a first in class P2X3 antagonist has been found to be efficacious in patients with refractory chronic cough, stimulating much interest in the development of therapies for this problem. The aim of this review is to summarize the current state of development of novel therapies acting both in the peripheral and central nervous systems. Most programs are focused on treating patients with refractory chronic cough, but chronic coughing is also a problem in common respiratory diseases in spite of standard care. However, unraveling of the pathophysiological mechanisms underlying cough will ultimately be needed to identify the relevant drug targets, better characterize patients, and match them to the most appropriate treatments.
Identifiants
pubmed: 31279461
pii: S2213-2198(19)30431-3
doi: 10.1016/j.jaip.2019.04.027
pii:
doi:
Substances chimiques
Antitussive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
1731-1738Subventions
Organisme : Medical Research Council
ID : MR/K015141/1
Pays : United Kingdom
Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.