Mycofactocin is essential for the establishment of methylotrophy in Mycobacterium smegmatis.
Methanol dehydrogenase
Methylotrophic metabolism
Mycobacteria
Mycofactocin
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
03 09 2019
03 09 2019
Historique:
received:
24
06
2019
accepted:
01
07
2019
pubmed:
8
7
2019
medline:
2
6
2020
entrez:
8
7
2019
Statut:
ppublish
Résumé
Mycobacterium smegmatis possesses (N,N-dimethyl-4-nitrosoaniline)-dependent (NDMA) methanol dehydrogenase (Mno) to establish methylotrophy by utilizing methanol as the source of both carbon and energy. In this study, we show that Mno forms decamer and has NADPH as the bound cofactor. Interestingly, Mno uses NDMA and not NADP
Identifiants
pubmed: 31279528
pii: S0006-291X(19)31337-3
doi: 10.1016/j.bbrc.2019.07.008
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Nitroso Compounds
0
4-nitrosodimethylaniline
138-89-6
NADP
53-59-8
Alcohol Oxidoreductases
EC 1.1.-
alcohol dehydrogenase (acceptor)
EC 1.1.2.8
Methanol
Y4S76JWI15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1073-1077Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.