Evolving Trends for Selected Treatments of T1a Renal Cell Carcinoma.


Journal

Urology
ISSN: 1527-9995
Titre abrégé: Urology
Pays: United States
ID NLM: 0366151

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 17 04 2019
revised: 19 06 2019
accepted: 24 06 2019
pubmed: 8 7 2019
medline: 16 1 2020
entrez: 8 7 2019
Statut: ppublish

Résumé

To evaluate contemporary trends in the management of small renal masses and how patient age has impacted practice patterns. Using the NCDB Participant User File (PUF) from 2002 to 2015, we identified patients with T1a renal masses. The initial treatment was categorized as radical nephrectomy (RN), partial nephrectomy (PN), ablation, or active surveillance (AS). A multinominal logistic regression model was used to identify significant factors impacting treatment. We identified 75,691 patients for analysis. RN, PN, and ablation accounted for 28%, 52%, and 12%, respectively, while 8% were managed with AS. In the past decade the likelihood of undergoing PN, ablation, or surveillance compared to RN has consistently increased, independent of age, sex, race, comorbidity, tumor size, or institution. As age increased, patients were independently less likely to undergo PN and more likely to be managed with ablation or AS. Compared to patients under 40 years of age, patients between 70 and 79 were far less likely to undergo PN (RR 0.58, P< .01), and far more likely to undergo either ablation (RR 5.53, P< .01) or AS (RR 3.7, P< .01). Trends in small renal mass management continue to evolve, with PN supplanting RN over the past decade as the predominant surgical treatment. Age significantly impacts treatment selection, particularly in older cohorts whom are much more likely to undergo ablation or AS. While the use of minimally invasive therapies has increased over the past decade, AS lags behind despite quality data supporting its use. When controlling for multiple clinical factors, PN, ablation and surveillance have consistently increased in utilization compared to RN.

Identifiants

pubmed: 31279691
pii: S0090-4295(19)30604-1
doi: 10.1016/j.urology.2019.06.029
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

136-142

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Johnathan Doolittle (J)

Medical College of Wisconsin, Milwaukee, WI. Electronic address: jdoolittle@mcw.edu.

Joshua Piotrowski (J)

Medical College of Wisconsin, Milwaukee, WI.

Keegan Zuk (K)

Medical College of Wisconsin, Milwaukee, WI.

Kenneth Jacobsohn (K)

Medical College of Wisconsin, Milwaukee, WI.

Peter Langenstroer (P)

Medical College of Wisconsin, Milwaukee, WI.

William See (W)

Medical College of Wisconsin, Milwaukee, WI.

Scott Johnson (S)

Medical College of Wisconsin, Milwaukee, WI.

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Classifications MeSH