Immunological consequences following splenectomy in patients with liver cirrhosis.
T cell
hypersplenism
immune cell phenotype
immune status
liver cirrhosis
neutrophil-to-lymphocyte ratio
splenectomy
Journal
Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
06
10
2018
accepted:
16
05
2019
entrez:
9
7
2019
pubmed:
10
7
2019
medline:
10
7
2019
Statut:
ppublish
Résumé
The immune status in patients with liver cirrhosis is generally impaired due to concomitant hypersplenism. As the spleen is the largest lymphoid organ, deleterious events resulting from splenectomy are of concern in these patients. However, the immunological consequences after splenectomy have not yet been fully elucidated. In the present study, the immune status after splenectomy was comprehensively examined. Splenectomy was performed in 11 patients with liver cirrhosis and hypersplenism, and the immune status in peripheral blood was examined and compared before and at 1, 3 and 6 months after splenectomy. Splenectomy significantly lowered the neutrophil-to-lymphocyte ratio, due to a surge in lymphocytes in the peripheral circulation at 3 and 6 months after splenectomy. The frequency of cluster of differentiation (CD)4
Identifiants
pubmed: 31281459
doi: 10.3892/etm.2019.7640
pii: ETM-0-0-7640
pmc: PMC6591499
doi:
Types de publication
Journal Article
Langues
eng
Pagination
848-856Références
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