Testosterone levels in men with chronic migraine.
Hypogonadism
Hypothalamus
Migraine
Neurology
Testosterone
Journal
Neurology international
ISSN: 2035-8385
Titre abrégé: Neurol Int
Pays: Switzerland
ID NLM: 101551564
Informations de publication
Date de publication:
18 Jun 2019
18 Jun 2019
Historique:
received:
21
02
2019
accepted:
14
04
2019
entrez:
9
7
2019
pubmed:
10
7
2019
medline:
10
7
2019
Statut:
epublish
Résumé
Chronic migraine is a frequent and debilitating condition affecting 14% of the general population. This prospective observational pilot study investigated whether men with chronic migraine have lower than expected total serum testosterone levels. We identified 14 men ages 26-51 at our Institution who fulfilled the ICHD-3b criteria for chronic migraine and obtained serum total testosterone levels. The mean total testosterone level in our 14 patients was 322 ng/dL (range: 120-542 ng/dL) which is in the lower 5% of the reference range for our laboratory (300-1080 ng/dL). Men with chronic migraine had lower total testosterone levels compared to published agematched normative median values by a median difference of 62 ng/dL (P=0.0494). This finding suggests that hypothalamic regulation is altered in patients with chronic migraine. Further studies are warranted to determine whether testosterone supplementation in men with chronic migraine reduces the number of headaches or the associated symptoms of hypogonadism.
Identifiants
pubmed: 31281602
doi: 10.4081/ni.2019.8079
pmc: PMC6589638
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8079Déclaration de conflit d'intérêts
Conflict of interest: the authors declare no potential conflict of interest.
Références
J Neurol Neurosurg Psychiatry. 2001 Dec;71(6):747-51
pubmed: 11723194
Neurol Sci. 2007 May;28 Suppl 2:S198-202
pubmed: 17508170
Headache. 2007 Nov-Dec;47(10):1418-26
pubmed: 18052951
Cephalalgia. 2009 Aug;29(8):809-17
pubmed: 19604254
Dev Neurobiol. 2009 Oct;69(12):825-35
pubmed: 19658088
Maturitas. 2012 Apr;71(4):385-8
pubmed: 22310106
Nat Rev Endocrinol. 2013 Jul;9(7):414-24
pubmed: 23591366
J Headache Pain. 2013 May 29;14:46
pubmed: 23718759
Cephalalgia. 2013 Jul;33(9):629-808
pubmed: 23771276
Front Neuroendocrinol. 2014 Apr;35(2):197-220
pubmed: 24246855
Eur Urol. 2015 Jan;67(1):176-177
pubmed: 25199721
PLoS One. 2014 Oct 08;9(10):e109346
pubmed: 25295520
Headache. 2015 Jan;55(1):21-34
pubmed: 25600719
J Neurosci. 2015 Apr 29;35(17):6619-29
pubmed: 25926442
J Headache Pain. 2016 Dec;17(1):104
pubmed: 27844455
J Urol. 2018 Jan;199(1):257-265
pubmed: 28728990
J Clin Neurosci. 2018 Apr;50:165-171
pubmed: 29366620
Investig Clin Urol. 2018 Nov;59(6):399-409
pubmed: 30402573
J Headache Pain. 2018 Nov 29;19(1):117
pubmed: 30497379
Cephalalgia. 1983 Mar;3(1):41-4
pubmed: 6850820
Cephalalgia. 1993 Oct;13(5):309-17
pubmed: 8242722