Increased Fecal
Lactobacillus
environmental enteric dysfunction
fecal microbiome
hydrogen breath testing
small intestine bacterial overgrowth
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
30
12
2018
accepted:
30
05
2019
entrez:
9
7
2019
pubmed:
10
7
2019
medline:
10
7
2019
Statut:
epublish
Résumé
Glucose hydrogen breath testing is a noninvasive test for small intestine bacterial overgrowth (SIBO). A positive glucose hydrogen breath test is common in children from low-income countries and has been found to be associated with malnutrition as measured by stunted growth. The microbiome associated with positive breath testing is relatively unstudied. We performed 16 S V4 rDNA microbiome analysis on the stool of 90 Bangladeshi children aged 2 years from an impoverished neighborhood who were tested at the same time for SIBO by glucose hydrogen breath testing. Data were analyzed by linear discriminant analysis effect size with SIBO as the outcome. Any selected genera were tested individually by Wilcoxon's rank-sum test to ensure that linear discriminant analysis effect size results were not outlier-skewed. Linear discriminant analysis effect size analysis identified These results suggest that glucose hydrogen breath test positivity in children from low-income settings may be due to an upper intestinal
Sections du résumé
BACKGROUND
BACKGROUND
Glucose hydrogen breath testing is a noninvasive test for small intestine bacterial overgrowth (SIBO). A positive glucose hydrogen breath test is common in children from low-income countries and has been found to be associated with malnutrition as measured by stunted growth. The microbiome associated with positive breath testing is relatively unstudied.
METHODS
METHODS
We performed 16 S V4 rDNA microbiome analysis on the stool of 90 Bangladeshi children aged 2 years from an impoverished neighborhood who were tested at the same time for SIBO by glucose hydrogen breath testing. Data were analyzed by linear discriminant analysis effect size with SIBO as the outcome. Any selected genera were tested individually by Wilcoxon's rank-sum test to ensure that linear discriminant analysis effect size results were not outlier-skewed.
RESULTS
RESULTS
Linear discriminant analysis effect size analysis identified
CONCLUSIONS
CONCLUSIONS
These results suggest that glucose hydrogen breath test positivity in children from low-income settings may be due to an upper intestinal
Identifiants
pubmed: 31281862
doi: 10.1093/ofid/ofz266
pii: ofz266
pmc: PMC6602902
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofz266Subventions
Organisme : NICHD NIH HHS
ID : K12 HD000850
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI043596
Pays : United States
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