Can Adults with Mild Cognitive Impairment Build Cognitive Reserve and Learn Mindfulness Meditation? Qualitative Theme Analyses from a Small Pilot Study.
Alzheimer’s disease
meditation
mild cognitive impairment
mindfulness
randomized clinical trial
yoga
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
10
7
2019
medline:
10
10
2020
entrez:
9
7
2019
Statut:
ppublish
Résumé
High levels of chronic stress negatively impact the hippocampus and are associated with increased incidence of mild cognitive impairment (MCI) and Alzheimer's disease. While mindfulness meditation may mitigate the effects of chronic stress, it is uncertain if adults with MCI have the capacity to learn mindfulness meditation. 14 adults with MCI were randomized 2:1 to Mindfulness Based Stress Reduction (MBSR) or a wait-list control group. We conducted qualitative interviews with those who completed MBSR. Transcribed interviews were: a) coded using an emergent themes inductive approach informed by grounded theory; b) rated 0-10, with higher scores reflecting greater perceived benefit from, and understanding of, mindfulness meditation. Ratings were correlated with daily home practice times and baseline level of cognitive function. Seven themes emerged from the interviews: positive perceptions of class; development of mindfulness skills, including meta-cognition; importance of the group experience; enhanced well-being; shift in MCI perspective; decreased stress reactivity and increased relaxation; improvement in interpersonal skills. Ratings of perceived benefit and understanding ranged from 2-10 (mean = 7) and of 0-9.5 (mean = 6), respectively. Many participants experienced substantial benefit/understanding, some had moderate, and a few had minimal benefit/understanding. Understanding the key concepts of mindfulness was highly positively correlated with ≥20 minutes/day of home practice (r = 0.90) but not with baseline cognitive function (r = 0.13). Most adults with MCI were able to learn mindfulness meditation and had improved MCI acceptance, self-efficacy, and social engagement. Cognitive reserve may be enhanced through a mindfulness meditation program even in patients with MCI.
Sections du résumé
BACKGROUND/OBJECTIVE
High levels of chronic stress negatively impact the hippocampus and are associated with increased incidence of mild cognitive impairment (MCI) and Alzheimer's disease. While mindfulness meditation may mitigate the effects of chronic stress, it is uncertain if adults with MCI have the capacity to learn mindfulness meditation.
METHODS
14 adults with MCI were randomized 2:1 to Mindfulness Based Stress Reduction (MBSR) or a wait-list control group. We conducted qualitative interviews with those who completed MBSR. Transcribed interviews were: a) coded using an emergent themes inductive approach informed by grounded theory; b) rated 0-10, with higher scores reflecting greater perceived benefit from, and understanding of, mindfulness meditation. Ratings were correlated with daily home practice times and baseline level of cognitive function.
RESULTS
Seven themes emerged from the interviews: positive perceptions of class; development of mindfulness skills, including meta-cognition; importance of the group experience; enhanced well-being; shift in MCI perspective; decreased stress reactivity and increased relaxation; improvement in interpersonal skills. Ratings of perceived benefit and understanding ranged from 2-10 (mean = 7) and of 0-9.5 (mean = 6), respectively. Many participants experienced substantial benefit/understanding, some had moderate, and a few had minimal benefit/understanding. Understanding the key concepts of mindfulness was highly positively correlated with ≥20 minutes/day of home practice (r = 0.90) but not with baseline cognitive function (r = 0.13).
CONCLUSIONS
Most adults with MCI were able to learn mindfulness meditation and had improved MCI acceptance, self-efficacy, and social engagement. Cognitive reserve may be enhanced through a mindfulness meditation program even in patients with MCI.
Identifiants
pubmed: 31282418
pii: JAD190191
doi: 10.3233/JAD-190191
pmc: PMC6753379
mid: NIHMS1050903
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
825-842Subventions
Organisme : NCCIH NIH HHS
ID : K24 AT000589
Pays : United States
Organisme : NCCIH NIH HHS
ID : T32 AT000051
Pays : United States
Organisme : NCCIH NIH HHS
ID : K01 AT008219
Pays : United States
Organisme : NCCIH NIH HHS
ID : K23 AT009218
Pays : United States
Organisme : NCCIH NIH HHS
ID : K23 AT008406
Pays : United States
Organisme : NCCIH NIH HHS
ID : K01 AT003459
Pays : United States
Organisme : NCCIH NIH HHS
ID : K24 AT004095
Pays : United States
Organisme : NCCIH NIH HHS
ID : K24 AT009465
Pays : United States
Références
Neuroreport. 2000 May 15;11(7):1581-5
pubmed: 10841380
J Anat. 2000 Nov;197 Pt 4:553-62
pubmed: 11197528
Lancet. 2001 Aug 11;358(9280):483-8
pubmed: 11513933
Gen Hosp Psychiatry. 2001 Jul-Aug;23(4):183-92
pubmed: 11543844
J Pers Soc Psychol. 2003 Feb;84(2):377-89
pubmed: 12585811
Health Psychol. 2003 Mar;22(2):210-9
pubmed: 12683741
Neurology. 2003 Dec 9;61(11):1479-85
pubmed: 14663028
Arch Neurol. 2004 Jan;61(1):59-66
pubmed: 14732621
J Psychosom Res. 2004 Jul;57(1):35-43
pubmed: 15256293
Arch Clin Neuropsychol. 2004 Aug;19(5):653-60
pubmed: 15271409
Neurology. 2005 Jan 25;64(2):380-2
pubmed: 15668449
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12523-8
pubmed: 16888038
JAMA. 2006 Dec 20;296(23):2805-14
pubmed: 17179457
Arch Gen Psychiatry. 2007 Feb;64(2):234-40
pubmed: 17283291
Neurology. 2007 Jun 12;68(24):2085-92
pubmed: 17562829
Ann Intern Med. 2008 Mar 18;148(6):427-34
pubmed: 18347351
JAMA. 2008 Sep 3;300(9):1027-37
pubmed: 18768414
Soc Cogn Affect Neurosci. 2008 Mar;3(1):55-61
pubmed: 19015095
Exp Aging Res. 2009 Jan-Mar;35(1):45-60
pubmed: 19173101
Neuroimage. 2009 Apr 15;45(3):672-8
pubmed: 19280691
J Clin Psychol. 2009 Jun;65(6):627-38
pubmed: 19309694
J Geriatr Psychiatry Neurol. 2009 Jun;22(2):103-9
pubmed: 19417219
J Psychosom Res. 2010 Jan;68(1):29-36
pubmed: 20004298
Arch Neurol. 2010 Jan;67(1):71-9
pubmed: 20065132
Res Gerontol Nurs. 2009 Apr;2(2):112-21
pubmed: 20077972
J Alzheimers Dis. 2010;20(2):517-26
pubmed: 20164557
J Altern Complement Med. 2010 Feb;16(2):157-63
pubmed: 20180688
Clin Psychol Rev. 2010 Nov;30(7):890-905
pubmed: 20451313
Psychiatry Res. 2011 Jan 30;191(1):36-43
pubmed: 21071182
Clin Psychol Psychother. 2011 Jan-Feb;18(1):80-93
pubmed: 21226129
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22
pubmed: 21282661
Int Psychogeriatr. 2011 Oct;23(8):1222-30
pubmed: 21385519
Philos Ethics Humanit Med. 2011 Apr 07;6:6
pubmed: 21473781
Neurology. 2011 Oct 18;77(16):1524-31
pubmed: 21975202
J Int Neuropsychol Soc. 2011 Nov;17(6):998-1005
pubmed: 22040898
J Alzheimers Dis. 2012;28(1):25-32
pubmed: 22246233
Alzheimers Dement. 2012;8(2):114-20
pubmed: 22404853
Am J Geriatr Psychiatry. 2012 May;20(5):416-24
pubmed: 22522960
Acad Med. 2012 Jun;87(6):815-9
pubmed: 22534599
J Am Med Dir Assoc. 2012 Jul;13(6):568.e15-20
pubmed: 22579072
Psychol Med. 2013 May;43(5):911-20
pubmed: 22954311
Am J Geriatr Psychiatry. 2013 Jul;21(7):685-95
pubmed: 23567400
Am J Geriatr Psychiatry. 2014 Apr;22(4):362-9
pubmed: 23567426
J Am Geriatr Soc. 2013 Apr;61(4):642-5
pubmed: 23581918
Ann N Y Acad Sci. 2014 Jan;1307:112-123
pubmed: 23924172
Clin Geriatr Med. 2013 Nov;29(4):773-89
pubmed: 24094296
Neurosci Lett. 2013 Nov 27;556:15-9
pubmed: 24120430
Ann N Y Acad Sci. 2014 Jan;1307:89-103
pubmed: 24571182
Int J Geriatr Psychiatry. 2014 Oct;29(10):991-1000
pubmed: 24677282
Front Aging Neurosci. 2014 Apr 22;6:76
pubmed: 24795629
Behav Brain Res. 2015 Jan 1;276:199-212
pubmed: 24893317
Aging Ment Health. 2015;19(4):353-62
pubmed: 25022459
Conscious Cogn. 2014 Aug;28:64-80
pubmed: 25038535
Am J Alzheimers Dis Other Demen. 2015 May;30(3):257-67
pubmed: 25154985
JAMA. 2014 Dec 17;312(23):2551-61
pubmed: 25514304
Neurology. 2015 Mar 3;84(9):935-43
pubmed: 25653291
PLoS One. 2015 Feb 11;10(2):e0113367
pubmed: 25671576
Nat Rev Neurosci. 2015 Apr;16(4):213-25
pubmed: 25783612
J Alzheimers Dis. 2015;48(1):1-12
pubmed: 26445019
J Alzheimers Dis. 2015;49(2):387-98
pubmed: 26484900
J Alzheimers Dis. 2015;50(1):217-32
pubmed: 26639952
Complement Ther Med. 2016 Feb;24:34-9
pubmed: 26860799
Neuroimage. 2016 Jul 1;134:305-313
pubmed: 27033686
J Alzheimers Dis. 2016;52(2):673-84
pubmed: 27060939
J Alzheimers Dis. 2016 Apr 5;52(2):757-74
pubmed: 27060951
J Alzheimers Dis. 2016 Apr 8;52(4):1277-98
pubmed: 27079708
Complement Ther Med. 2016 Jun;26:98-107
pubmed: 27261989
J Alzheimers Dis. 2016 Nov 1;55(1):1-18
pubmed: 27636853
J Alzheimers Dis. 2017;56(1):275-286
pubmed: 27983555
Int Psychogeriatr. 2017 Apr;29(4):557-567
pubmed: 28088925
J Alzheimers Dis. 2017;56(3):899-916
pubmed: 28106552
Int J Geriatr Psychiatry. 2017 Dec;32(12):e123-e131
pubmed: 28170104
J Clin Psychiatry. 2017 Jul;78(7):e734-e743
pubmed: 28686822
Behav Modif. 2017 Nov;41(6):764-787
pubmed: 28689469
Cerebrum. 2017 Mar 01;2017:
pubmed: 28698774
Pediatr Cardiol. 2017 Oct;38(7):1415-1425
pubmed: 28702717
BMC Geriatr. 2017 Jul 13;17(1):144
pubmed: 28705185
Neurology. 2018 Jan 16;90(3):126-135
pubmed: 29282327
Rev Neurosci. 2018 Sep 25;29(7):791-804
pubmed: 29466242
Res Gerontol Nurs. 2018 May 1;11(3):137-150
pubmed: 29498748
Alzheimers Res Ther. 2018 Jun 22;10(1):57
pubmed: 29933746
Front Psychol. 2018 Jun 13;9:982
pubmed: 29951027
Complement Ther Med. 2018 Oct;40:215-221
pubmed: 30219453
J Alzheimers Dis. 2018;66(3):947-970
pubmed: 30320574
Am J Geriatr Psychiatry. 2019 Feb;27(2):188-197
pubmed: 30413292
J Alzheimers Dis Rep. 2017 Dec 2;1(1):181-193
pubmed: 30480237
Lancet Neurol. 2019 Jan;18(1):88-106
pubmed: 30497964
Psychoneuroendocrinology. 1997 May;22(4):277-95
pubmed: 9226731
Hum Brain Mapp. 1999;7(2):98-105
pubmed: 9950067