No association between smoking and sentinel lymph node metastasis and survival in cutaneous melanoma.
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
01
04
2019
accepted:
21
06
2019
pubmed:
10
7
2019
medline:
28
5
2020
entrez:
9
7
2019
Statut:
ppublish
Résumé
There is little evidence that smoking is associated with metastasis in patients with cutaneous melanoma. Using a propensity score matching analysis, we assessed whether smoking was associated with a higher rate of sentinel lymph node (SLN) metastasis and worse survival in these patients. Retrospective cohort study at a referral hospital for melanoma. We studied 762 patients with known smoking status from the melanoma database of the Instituto Valenciano de Oncología who underwent SLN biopsy between 1 January 2000 and 31 December 2016. The patients were matched by smoking status. The matching procedure was implemented using three logistic regression models featuring never vs. former smokers, never vs. current smokers and former vs. current smokers. The study outcomes were disease-free survival (DFS), melanoma-specific survival (MSS), overall survival (OS) and SLN status. The following groups were formed based on the propensity matching scores: 114 pairs of smokers vs. never smokers, 113 pairs of smokers vs. former smokers and 174 pairs of never smokers vs. former smokers. Smoking status was not associated with SLN metastasis or with DFS, MSS or OS in any of the three groups. Smoking does not influence SLN metastasis or survival in patients with cutaneous melanoma.
Sections du résumé
BACKGROUND
BACKGROUND
There is little evidence that smoking is associated with metastasis in patients with cutaneous melanoma.
OBJECTIVE
OBJECTIVE
Using a propensity score matching analysis, we assessed whether smoking was associated with a higher rate of sentinel lymph node (SLN) metastasis and worse survival in these patients.
METHODS
METHODS
Retrospective cohort study at a referral hospital for melanoma. We studied 762 patients with known smoking status from the melanoma database of the Instituto Valenciano de Oncología who underwent SLN biopsy between 1 January 2000 and 31 December 2016. The patients were matched by smoking status. The matching procedure was implemented using three logistic regression models featuring never vs. former smokers, never vs. current smokers and former vs. current smokers. The study outcomes were disease-free survival (DFS), melanoma-specific survival (MSS), overall survival (OS) and SLN status.
RESULTS
RESULTS
The following groups were formed based on the propensity matching scores: 114 pairs of smokers vs. never smokers, 113 pairs of smokers vs. former smokers and 174 pairs of never smokers vs. former smokers. Smoking status was not associated with SLN metastasis or with DFS, MSS or OS in any of the three groups.
CONCLUSION
CONCLUSIONS
Smoking does not influence SLN metastasis or survival in patients with cutaneous melanoma.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2283-2290Informations de copyright
© 2019 European Academy of Dermatology and Venereology.
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