Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology.
invasive fungal disease
lomentosporiosis
scedosporiosis
solid organ transplantation
Journal
Transplant infectious disease : an official journal of the Transplantation Society
ISSN: 1399-3062
Titre abrégé: Transpl Infect Dis
Pays: Denmark
ID NLM: 100883688
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
31
01
2019
revised:
24
06
2019
accepted:
01
07
2019
pubmed:
10
7
2019
medline:
27
2
2020
entrez:
9
7
2019
Statut:
ppublish
Résumé
Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years. This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.
Sections du résumé
BACKGROUND
BACKGROUND
Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients.
METHODS
METHODS
We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017.
RESULTS
RESULTS
A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years.
CONCLUSIONS
CONCLUSIONS
This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13141Subventions
Organisme : Medical Research Council
ID : G0701652
Pays : United Kingdom
Investigateurs
Claudia Nagel
(C)
Glen Westall
(G)
Orla Morrissey
(O)
Daniel Chambers
(D)
Stephan Eschertzhuber
(S)
Julien Coussement
(J)
Christiane Knoop
(C)
Robin Vos
(R)
Lieven Dupont
(L)
Michel Dumonceaux
(M)
Silvia Vidal Campos
(SV)
Dima Kabbani
(D)
Carlos Cervera
(C)
Me-Linh Luong
(ML)
Elodie Blanchard
(E)
Agathe Sénéchal
(A)
Jérôme Le Pavec
(JL)
Olivier Brugière
(O)
Veronique Boussaud
(V)
Romain Guillemain
(R)
Jean-Francois Bervar
(JF)
Johanna Claustre
(J)
Alain Haloun
(A)
Sandrine Hirschi
(S)
Martine Reynaud
(M)
Clément Picard
(C)
Nikolaus Kneidinger
(N)
Jens Gottlieb
(J)
Emmanuel Roilides
(E)
Hossein Zarrinfar
(H)
Lorenzo Rosso
(L)
Letizia Corinna Morlacchi
(LC)
Andrea Dell'Amore
(A)
Monica Loy
(M)
Claudy Oliveira Dos Santos
(COD)
Jordi Rello
(J)
Victor Monforte
(V)
Maria Teresa Martin-Gomez
(MT)
Francisco López Medrano
(FL)
Mario Fernández-Ruiz
(M)
Amparo Sole
(A)
Jose M Cifrian
(JM)
Dionysios Neofytos
(D)
Nicolas Mueller
(N)
Christian Benden
(C)
Anne Kathrin Brill
(AK)
Esen Kiyan
(E)
Kate Gould
(K)
Effrossyni Gkrania-Klotsas
(E)
Miruna David
(M)
Sam Weigt
(S)
Eun Jeong Kwak
(EJ)
Fernanda Silveira
(F)
Denis Hadjiliadis
(D)
John Baddley
(J)
Lara Danziger-Isakov
(L)
Sangeeta Bhorade
(S)
Michael Ison
(M)
Cameron Wolfe
(C)
Saima Aslam
(S)
Marie Budem
(M)
Ana Musetti
(A)
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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