Enhanced cancer therapy with pH-dependent and aptamer functionalized doxorubicin loaded polymeric (poly D, L-lactic-co-glycolic acid) nanoparticles.
A549 Cells
Animals
Antineoplastic Agents
/ pharmacokinetics
Aptamers, Nucleotide
/ chemistry
Doxorubicin
/ pharmacokinetics
Drug Carriers
/ chemistry
Drug Liberation
Female
Humans
Hydrogen-Ion Concentration
Mice
Mice, Inbred BALB C
NIH 3T3 Cells
Nanoparticles
/ chemistry
Neoplasms
/ drug therapy
Oligodeoxyribonucleotides
/ chemistry
Polylactic Acid-Polyglycolic Acid Copolymer
/ chemistry
Povidone
/ chemistry
Xenograft Model Antitumor Assays
Aptamer
Cancer therapy
Doxorubicin
Drug delivery
Nanocomposites
Polymers
Journal
Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
25
05
2019
revised:
02
07
2019
accepted:
04
07
2019
pubmed:
10
7
2019
medline:
17
3
2020
entrez:
9
7
2019
Statut:
ppublish
Résumé
Aptamer based drug delivery systems are gaining the importance in anticancer therapy due to their targeted drug delivery efficiency without harming the normal cells. The present work formulated the pH-dependent aptamer functionalized polymer-based drug delivery system against human lung cancer. The prepared aptamer functionalized doxorubicin (DOX) loaded poly (D, L-lactic-co-glycolic acid) (PLGA), poly (N-vinylpyrrolidone) (PVP) nanoparticles (APT-DOX-PLGA-PVP NPs) were spherical in shape with an average size of 87.168 nm. The crystallography and presence of the PLGA (poly (D, L-lactic-co-glycolic acid)) and DOX (doxorubicin) in APT-DOX-PLGA-PVP NPs were indicated by the X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), and
Identifiants
pubmed: 31283911
pii: S0003-9861(19)30407-2
doi: 10.1016/j.abb.2019.07.004
pii:
doi:
Substances chimiques
AGRO 100
0
Antineoplastic Agents
0
Aptamers, Nucleotide
0
Drug Carriers
0
Oligodeoxyribonucleotides
0
Polylactic Acid-Polyglycolic Acid Copolymer
1SIA8062RS
Doxorubicin
80168379AG
Povidone
FZ989GH94E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
143-151Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.