Hippocampal Neurogenesis in Conditions of Chronic Stress Induced by Sciatic Nerve Injury in the Rat.
Animals
Antigens, CD
/ metabolism
Cell Proliferation
Chronic Disease
Dentate Gyrus
/ pathology
Doublecortin Domain Proteins
Doublecortin Protein
Hippocampus
/ pathology
Macrophages
/ pathology
Male
Microglia
/ pathology
Microtubule-Associated Proteins
/ metabolism
Microtubules
/ metabolism
Neuralgia
/ pathology
Neurogenesis
Neuropeptides
/ metabolism
Proliferating Cell Nuclear Antigen
/ metabolism
Rats, Wistar
Sciatic Nerve
/ injuries
Stress, Physiological
CD163
CD86
DCX
Hippocampus
PCNA
Sciatic nerve injury
iba-1
Journal
Cells, tissues, organs
ISSN: 1422-6421
Titre abrégé: Cells Tissues Organs
Pays: Switzerland
ID NLM: 100883360
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
04
2019
accepted:
27
05
2019
pubmed:
10
7
2019
medline:
14
3
2020
entrez:
9
7
2019
Statut:
ppublish
Résumé
The dentate gyrus of the hippocampus is the primary location of adult neurogenesis, which is affected by a variety of external and internal factors, including activity of surrounding glial cells. This study concerns alterations in hippocampal neurogenesis and changes in activity of both proinflammatory and neuroprotective microglia/macrophages after sciatic nerve injury in the rat. Here, we demonstrated that the chronic pain induced by a peripheral nerve injury manifests in the hippocampus by a decrease in proliferation (PCNA+) and neurogenesis (DCX+), an increase in proinflammatory cytokines (CD86+), and a reduction in neuroprotective (CD163+) microglia/macrophages. We suggest that a pathological increase microglia/macrophage activity is the cause of neurogenesis suppression observed in chronic neuropathic pain.
Identifiants
pubmed: 31284284
pii: 000501236
doi: 10.1159/000501236
doi:
Substances chimiques
Antigens, CD
0
Dcx protein, rat
0
Doublecortin Domain Proteins
0
Doublecortin Protein
0
Microtubule-Associated Proteins
0
Neuropeptides
0
Proliferating Cell Nuclear Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-68Informations de copyright
© 2019 S. Karger AG, Basel.