Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction.
brexpiprazole
glioblastoma
glioma stem cell
osimertinib
survivin
xenograft
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Jul 2019
05 Jul 2019
Historique:
received:
29
05
2019
revised:
26
06
2019
accepted:
03
07
2019
entrez:
10
7
2019
pubmed:
10
7
2019
medline:
10
7
2019
Statut:
epublish
Résumé
Glioblastoma is a primary brain tumor associated with a poor prognosis due to its high chemoresistance capacity. Cancer stem cells (CSCs) are one of the mechanisms of chemoresistance. Although therapy targeting CSCs is promising, strategies targeting CSCs remain unsuccessful. Abnormal activation of epidermal growth factor receptors (EGFRs) due to amplification, mutation, or both of the
Identifiants
pubmed: 31284441
pii: cancers11070947
doi: 10.3390/cancers11070947
pmc: PMC6679129
pii:
doi:
Types de publication
Journal Article
Langues
eng
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