Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Hepatic Fat Accretion and Energy and Fatty Acids Profile of Fetal Tissues.
Adiposity
/ drug effects
Animals
Dietary Supplements
Disease Models, Animal
Energy Metabolism
/ drug effects
Fatty Acids
/ metabolism
Female
Fetal Growth Retardation
/ metabolism
Fetus
/ drug effects
Lipid Peroxidation
/ drug effects
Liver
/ drug effects
Maternal Exposure
Muscle, Skeletal
/ drug effects
Phenylethyl Alcohol
/ analogs & derivatives
Pregnancy
Sus scrofa
antioxidants
intrauterine-growth-restriction
pregnancy
swine-model
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
05 Jul 2019
05 Jul 2019
Historique:
received:
16
06
2019
revised:
29
06
2019
accepted:
01
07
2019
entrez:
10
7
2019
pubmed:
10
7
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Maternal supplementation with hydroxytyrosol, a polyphenol present in olive leaves and fruits, is a highly promising strategy to improve the oxidative and metabolic status of fetuses at risk of intrauterine growth restriction, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine whether hydroxytyrosol, by preventing lipid peroxidation, may influence the fat accretion and energy homeostasis in the liver, as well as the fatty acid composition in the liver and muscle. The results indicate that hydroxytyrosol treatment significantly decreased the energy content of the fetal liver, without affecting fat accretion, and caused significant changes in the availability of fatty acids. There were significant increases in the amount of total polyunsaturated fatty acids, omega-3 and omega-6, which are highly important for adequate fetal tissue development. However, there were increases in the omega-6/omega-3 ratio and the desaturation index, which make further studies necessary to determine possible effects on the pro/anti-inflammatory status of the fetuses.
Identifiants
pubmed: 31284510
pii: nu11071534
doi: 10.3390/nu11071534
pmc: PMC6682965
pii:
doi:
Substances chimiques
Fatty Acids
0
3,4-dihydroxyphenylethanol
10597-60-1
Phenylethyl Alcohol
ML9LGA7468
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2013-48121-C3-R
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2016-79321-C2-2-R
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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