Comparative in Vitro Cytotoxicity of Realistic Doses of Benchmark Multi-Walled Carbon Nanotubes towards Macrophages and Airway Epithelial Cells.
airway epithelium
barrier permeability
inflammation
macrophages
multiwalled carbon nanotubes
realistic doses
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
06 Jul 2019
06 Jul 2019
Historique:
received:
13
06
2019
revised:
28
06
2019
accepted:
03
07
2019
entrez:
10
7
2019
pubmed:
10
7
2019
medline:
10
7
2019
Statut:
epublish
Résumé
Multi-walled carbon nanotubes (MWCNT) have many outstanding physical and chemical properties that make them useful in many applications in nanotechnology. However, these properties are reported to be potentially harmful for the human body. The effects of low and realistic doses of three well-characterized preparations of MWCNT, obtained from the Joint Research Centre (JRC) (NM-400, NM-401, and NM-402), were assessed in two murine macrophage lines, Raw264.7, of peritoneal origin, and MH-S, derived from alveolar macrophages. Macrophage viability, evaluated with two distinct methods, was significantly lowered by NM-401 (needle-like, average length 4 μm, diameter 67 nm) with IC
Identifiants
pubmed: 31284615
pii: nano9070982
doi: 10.3390/nano9070982
pmc: PMC6669589
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Seventh Framework Programme
ID : NMP4-LA-2011-26321
Organisme : Horizon 2020 Framework Programme
ID : NMBP n. 760928
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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