Phenotypic and Genotypic Characterization of
UPEC
Uropathogenic E. coli
antibiotic resistance
genomics
kidney transplantation
phylogeny
virulence traits
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
07 Jul 2019
07 Jul 2019
Historique:
received:
03
06
2019
revised:
01
07
2019
accepted:
05
07
2019
entrez:
10
7
2019
pubmed:
10
7
2019
medline:
10
7
2019
Statut:
epublish
Résumé
Urinary tract infection (UTI), frequently caused by uropathogenic Escherichia coli (UPEC), is the most common infection after kidney transplantation (KTx). Untreated, it can lead to urosepsis and impairment of the graft function. We questioned whether the UPEC isolated from KTx patients differed from the UPEC of non-KTx patients. Therefore, we determined the genome sequences of 182 UPEC isolates from KTx and control patients in a large German university clinic and pheno- and genotypically compared these two isolated groups. Resistance to the β-lactams, trimethoprim or trimethoprim/sulfamethoxazole was significantly higher among UPEC from KTx than from control patients, whereas both the isolated groups were highly susceptible to fosfomycin. Accordingly, the gene content conferring resistance to β-lactams or trimethoprim, but also to aminoglycosides, was significantly higher in KTx than in control UPEC isolates.
Identifiants
pubmed: 31284699
pii: jcm8070988
doi: 10.3390/jcm8070988
pmc: PMC6678207
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1009, TP B05, and B10
Organisme : University of Münster, Medical Faculty of the University of Münster
ID : Medizinerkolleg MedK
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