Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis.
Active Transport, Cell Nucleus
Animals
Cell Proliferation
Cell Transformation, Neoplastic
Disease Models, Animal
Gene Expression
Genes, bcl-2
Genes, myc
Humans
Karyopherins
/ chemistry
Leukemia, B-Cell
/ genetics
Mice
Mutation
Nuclear Export Signals
Organ Specificity
/ genetics
Protein Binding
Receptors, Cytoplasmic and Nuclear
/ chemistry
Structure-Activity Relationship
Exportin 1 Protein
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
11
03
2019
revised:
20
06
2019
accepted:
01
07
2019
pubmed:
10
7
2019
medline:
13
8
2020
entrez:
10
7
2019
Statut:
ppublish
Résumé
Altered expression of XPO1, the main nuclear export receptor in eukaryotic cells, has been observed in cancer, and XPO1 has been a focus of anticancer drug development. However, mechanistic evidence for cancer-specific alterations in XPO1 function is lacking. Here, genomic analysis of 42,793 cancers identified recurrent and previously unrecognized mutational hotspots in
Identifiants
pubmed: 31285298
pii: 2159-8290.CD-19-0298
doi: 10.1158/2159-8290.CD-19-0298
pmc: PMC6774834
mid: NIHMS1533928
doi:
Substances chimiques
Karyopherins
0
Nuclear Export Signals
0
Receptors, Cytoplasmic and Nuclear
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1452-1467Subventions
Organisme : NIH HHS
ID : U54 OD020355
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA230319
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207244
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA201247
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128239
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA218896
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI079087
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130724
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204749
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2019 American Association for Cancer Research.
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