Functional boundaries in the human cerebellum revealed by a multi-domain task battery.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
20
09
2018
accepted:
22
05
2019
pubmed:
10
7
2019
medline:
5
11
2019
entrez:
10
7
2019
Statut:
ppublish
Résumé
There is compelling evidence that the human cerebellum is engaged in a wide array of motor and cognitive tasks. A fundamental question centers on whether the cerebellum is organized into distinct functional subregions. To address this question, we employed a rich task battery designed to tap into a broad range of cognitive processes. During four functional MRI sessions, participants performed a battery of 26 diverse tasks comprising 47 unique conditions. Using the data from this multi-domain task battery, we derived a comprehensive functional parcellation of the cerebellar cortex and evaluated it by predicting functional boundaries in a novel set of tasks. The new parcellation successfully identified distinct functional subregions, providing significant improvements over existing parcellations derived from task-free data. Lobular boundaries, commonly used to summarize functional data, did not coincide with functional subdivisions. The new parcellation provides a functional atlas to guide future neuroimaging studies.
Identifiants
pubmed: 31285616
doi: 10.1038/s41593-019-0436-x
pii: 10.1038/s41593-019-0436-x
pmc: PMC8312478
mid: NIHMS1720742
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1371-1378Subventions
Organisme : NINDS NIH HHS
ID : R01 NS092079
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105839
Pays : United States
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
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