Posaconazole-Induced Hypertension Due to Inhibition of 11
11β-hydroxylase
11β-hydroxysteroid dehydrogenase
hypertension
hypokalemia
mineralocorticoid excess
posaconazole
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Jul 2019
01 Jul 2019
Historique:
received:
18
05
2019
accepted:
31
05
2019
entrez:
10
7
2019
pubmed:
10
7
2019
medline:
10
7
2019
Statut:
epublish
Résumé
We describe two cases of hypertension and hypokalemia due to mineralocorticoid excess caused by posaconazole treatment of coccidioidomycosis and rhinocerebral mucormycosis infections, respectively. Clinical laboratory evaluations, including a comprehensive analysis of blood and urine steroid profiles, revealed low renin and aldosterone and indicated as the underlying mechanism primarily a block of 11
Identifiants
pubmed: 31286100
doi: 10.1210/js.2019-00189
pii: 201900189
pmc: PMC6608555
doi:
Types de publication
Case Reports
Langues
eng
Pagination
1361-1366Références
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