Role of Macrophages in Pregnancy and Related Complications.
Decidualization
Human pregnancy
Macrophage
Polarity
Preeclampsia
VEGF
Journal
Archivum immunologiae et therapiae experimentalis
ISSN: 1661-4917
Titre abrégé: Arch Immunol Ther Exp (Warsz)
Pays: Switzerland
ID NLM: 0114365
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
14
12
2018
accepted:
28
06
2019
pubmed:
10
7
2019
medline:
23
1
2020
entrez:
10
7
2019
Statut:
ppublish
Résumé
Macrophages (MФs) are the leukocytes produced from differentiation of monocytes and are located in almost all tissues of human body. They are involved in various processes, such as phagocytosis, innate and adaptive immunity, proinflammatory (M1) and anti-inflammatory (M2) activity, depending on the tissue microenvironment. They play a crucial role in pregnancy, and their dysfunction or alteration of polarity is involved in pregnancy disorders, like preeclampsia, recurrent spontaneous abortion, infertility, intrauterine growth restriction, and preterm labor. About 50-60% of decidual leukocytes are natural killer (NK) cells followed by MФs (the second largest population). MФs are actively involved in trophoblast invasion, tissue and vascular remodeling during early pregnancy, besides their role as major antigen-presenting cells in the decidua. These cells have different phenotypes and polarities in different stages of pregnancy. They have also been observed to enhance tumor growth by their anti-inflammatory activity (M2 type) and prevent immunogenic rejection. Targeted alteration of polarity (M1-M2 or vice versa) could be a major focus in the future treatment of pregnancy complications. This review is focused on the role of MФs in pregnancy, their involvement in pregnancy disorders, and decidual MФs as possible therapeutic targets for the treatment of pregnancy complications.
Identifiants
pubmed: 31286151
doi: 10.1007/s00005-019-00552-7
pii: 10.1007/s00005-019-00552-7
pmc: PMC7140981
mid: NIHMS1573205
doi:
Substances chimiques
Vascular Endothelial Growth Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
295-309Subventions
Organisme : NICHD NIH HHS
ID : R01 HD088549
Pays : United States
Organisme : National Institute of Child Health and Human Development
ID : R01HD088549
Références
Am J Pathol. 2006 Feb;168(2):445-52
pubmed: 16436659
Biol Reprod. 2007 Mar;76(3):433-9
pubmed: 17108334
Fertil Steril. 1983 Mar;39(3):310-5
pubmed: 6681781
Biol Reprod. 2013 Jun 20;88(6):155
pubmed: 23553431
Immunol Rev. 2005 Aug;206:306-35
pubmed: 16048557
Mol Hum Reprod. 2012 Apr;18(4):204-15
pubmed: 22053055
J Immunol. 2013 Oct 1;191(7):3734-43
pubmed: 23997215
Placenta. 2005 Sep-Oct;26(8-9):591-6
pubmed: 16085037
Hum Reprod. 2019 Jan 01;34(1):25-36
pubmed: 30500923
Placenta. 2014 Feb;35 Suppl:S51-6
pubmed: 24215782
J Pathol. 2008 Jan;214(2):161-78
pubmed: 18161744
Immunol Invest. 2008;37(5):535-64
pubmed: 18716937
Am J Pathol. 2009 May;174(5):1959-71
pubmed: 19349361
J Cell Biol. 1995 Aug;130(3):503-6
pubmed: 7542656
Hum Reprod. 2005 Apr;20(4):1057-66
pubmed: 15746201
PLoS One. 2008 Apr 30;3(4):e2078
pubmed: 18446208
Immunol Lett. 2008 Jan 15;115(1):21-32
pubmed: 18055021
PLoS One. 2018 Jan 11;13(1):e0191040
pubmed: 29324807
Mol Hum Reprod. 2012 Nov;18(11):535-45
pubmed: 22763913
J Biol Chem. 2002 Feb 15;277(7):4816-22
pubmed: 11719510
J Endocrinol. 1998 Dec;159(3):459-67
pubmed: 9834463
Am J Pathol. 2011 Feb;178(2):709-17
pubmed: 21281803
J Reprod Immunol. 2004 Apr;61(2):87-98
pubmed: 15063632
Reprod Sci. 2010 Mar;17(3):209-18
pubmed: 20065301
Gynecol Obstet Invest. 2010;70(1):40-6
pubmed: 20160447
Infect Immun. 2009 Jan;77(1):85-97
pubmed: 18852237
J Immunol. 2000 Apr 1;164(7):3596-9
pubmed: 10725715
Am J Pathol. 2010 Nov;177(5):2472-82
pubmed: 20829438
J Reprod Immunol. 2013 Dec;100(2):109-17
pubmed: 24045115
J Clin Invest. 2008 Dec;118(12):3832-5
pubmed: 19033651
Biol Reprod. 2000 Apr;62(4):959-68
pubmed: 10727265
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3203-8
pubmed: 16492730
J Reprod Immunol. 2010 May;85(1):40-6
pubmed: 20356631
Yale J Biol Med. 2012 Mar;85(1):105-18
pubmed: 22461749
Immune Netw. 2015 Feb;15(1):16-26
pubmed: 25713505
Am J Obstet Gynecol. 2006 Jul;195(1):29-39
pubmed: 16579915
Science. 2002 Sep 13;297(5588):1867-70
pubmed: 12228717
Reproduction. 2009 Jul;138(1):177-84
pubmed: 19357130
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2191-8
pubmed: 23708119
Semin Cell Dev Biol. 2000 Apr;11(2):127-37
pubmed: 10873709
Placenta. 2012 Mar;33(3):188-94
pubmed: 22212249
Am J Reprod Immunol. 2009 Feb;61(2):136-46
pubmed: 19143677
Biol Reprod. 2004 Apr;70(4):1018-23
pubmed: 14681197
Placenta. 2001 Apr;22(4):309-16
pubmed: 11286566
Am J Reprod Immunol. 2004 Apr;51(4):275-82
pubmed: 15212680
Fertil Steril. 2010 Nov;94(6):2030-6
pubmed: 20338560
J Reprod Immunol. 2007 Dec;76(1-2):45-53
pubmed: 17499365
Reproduction. 2012 May;143(5):713-25
pubmed: 22454532
Biol Reprod. 2005 Sep;73(3):510-8
pubmed: 15878887
Front Immunol. 2019 Jan 10;9:3142
pubmed: 30687334
Am J Reprod Immunol. 2003 Dec;50(6):444-52
pubmed: 14750551
J Immunol. 2011 Feb 15;186(4):2633-42
pubmed: 21257965
Clin Nephrol. 2011 Mar;75(3):226-32
pubmed: 21329633
Clin Exp Reprod Med. 2011 Sep;38(3):119-25
pubmed: 22384430
Reprod Biol Endocrinol. 2003 Dec 02;1:119
pubmed: 14651752
Cancer Cell. 2013 Feb 11;23(2):249-62
pubmed: 23410977
Immunology. 1999 Feb;96(2):272-7
pubmed: 10233705
Placenta. 2007 May-Jun;28(5-6):571-6
pubmed: 17052752
Front Immunol. 2015 Feb 16;6:53
pubmed: 25762996
Cancer Res. 2001 Oct 1;61(19):7240-7
pubmed: 11585761
Nat Rev Immunol. 2003 Jan;3(1):23-35
pubmed: 12511873
Front Immunol. 2014 Nov 24;5:606
pubmed: 25505471
J Reprod Immunol. 2003 Aug;59(2):161-73
pubmed: 12896820
Nat Clin Pract Cardiovasc Med. 2005 Jun;2(6):309-15
pubmed: 16265535
Science. 1997 Sep 12;277(5332):1669-72
pubmed: 9287221
Am J Reprod Immunol. 1994 May;31(4):180-8
pubmed: 8060501
Biochim Biophys Acta. 2009 Aug;1796(1):11-8
pubmed: 19269310
Curr Pharm Des. 2009;15(4):365-79
pubmed: 19199964
J Clin Endocrinol Metab. 2004 Dec;89(12):6155-67
pubmed: 15579772
Placenta. 2003 Feb-Mar;24(2-3):181-90
pubmed: 12566245
Annu Rev Immunol. 2009;27:451-83
pubmed: 19105661
Vasc Cell. 2014 Aug 01;6:16
pubmed: 25101167
Mol Hum Reprod. 2002 Apr;8(4):385-91
pubmed: 11912287
Am J Reprod Immunol. 2010 Jun;63(6):460-71
pubmed: 20163399
Cancer Cell. 2013 Mar 18;23(3):277-86
pubmed: 23518347
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5767-72
pubmed: 19304799
J Innate Immun. 2012;4(5-6):509-28
pubmed: 22722900
Biol Reprod. 2011 Oct;85(4):788-97
pubmed: 21734258
Trends Immunol. 2004 Dec;25(12):677-86
pubmed: 15530839
Biol Reprod. 1998 Jun;58(6):1469-75
pubmed: 9623608
Hum Reprod Update. 2000 Jan-Feb;6(1):28-36
pubmed: 10711827
J Cell Biochem. 2003 Sep 1;90(1):187-96
pubmed: 12938167
Am J Reprod Immunol. 2015 Aug;74(2):100-9
pubmed: 25582625
Blood. 2003 Aug 15;102(4):1515-24
pubmed: 12689930
J Clin Invest. 2014 Nov;124(11):4941-52
pubmed: 25329693
Nat Rev Immunol. 2004 Jun;4(6):432-44
pubmed: 15173832
Reproduction. 2005 May;129(5):631-7
pubmed: 15855626
Eur J Immunol. 2011 Jul;41(7):2052-63
pubmed: 21480214
Placenta. 2017 Aug;56:44-52
pubmed: 28284455
Reprod Sci. 2008 May;15(5):437-47
pubmed: 18579853
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4560-5
pubmed: 15070757
Mediators Inflamm. 2014;2014:248963
pubmed: 24733960
Placenta. 2000 May;21(4):376-87
pubmed: 10833373
J Clin Endocrinol Metab. 2005 Jun;90(6):3680-7
pubmed: 15784708
Am J Reprod Immunol. 2004 Feb;51(2):117-22
pubmed: 14748837
Am J Reprod Immunol. 2010 Jun;63(6):434-44
pubmed: 20055791
Nat Rev Immunol. 2003 Oct;3(10):791-800
pubmed: 14502271
Clin Dev Immunol. 2012;2012:639342
pubmed: 22007254
J Immunol. 2011 Oct 1;187(7):3671-82
pubmed: 21890660
Immunol Rev. 2006 Oct;213:36-47
pubmed: 16972895
Obstet Gynecol. 1996 Jul;88(1):47-50
pubmed: 8684760
Fertil Steril. 2002 Mar;77(3):548-54
pubmed: 11872211
Front Immunol. 2014 Jun 30;5:298
pubmed: 25071761
Rev Reprod. 2000 May;5(2):63-6
pubmed: 10864849
Cancer Cell. 2011 Jan 18;19(1):31-44
pubmed: 21215706
Eur J Obstet Gynecol Reprod Biol. 2005 Dec 1;123(2):162-6
pubmed: 15894418
Placenta. 2002 Apr;23(4):274-80
pubmed: 11969337
Hum Reprod Update. 2000 Jan-Feb;6(1):16-27
pubmed: 10711826
Mol Hum Reprod. 2014 May;20(5):454-62
pubmed: 24464956
Front Biosci. 2008 Jan 01;13:453-61
pubmed: 17981560
J Exp Med. 2005 May 2;201(9):1487-502
pubmed: 15867096
J Biol Chem. 1996 Jul 26;271(30):17629-34
pubmed: 8663424
J Biol Chem. 2011 Oct 7;286(40):34941-50
pubmed: 21862594
Mol Reprod Dev. 1997 Jan;46(1):54-60; discussion 60-1
pubmed: 8981364
J Clin Invest. 2013 Aug;123(8):3472-87
pubmed: 23867505
Am J Reprod Immunol. 2009 Mar;61(3):253-60
pubmed: 19239428
Am J Obstet Gynecol. 2008 Jul;199(1):46.e1-6
pubmed: 18241824
Mol Cell Biol. 2005 Nov;25(21):9543-53
pubmed: 16227604
Ann N Y Acad Sci. 2011 Mar;1221:80-7
pubmed: 21401634
Oncotarget. 2014 Jul 30;5(14):5350-68
pubmed: 25051364
Lab Invest. 2001 Aug;81(8):1143-52
pubmed: 11502865
Proc Natl Acad Sci U S A. 1990 Jun;87(12):4828-32
pubmed: 2191302
Hum Reprod. 2003 Mar;18(3):616-20
pubmed: 12615835
Biol Chem. 2007 Nov;388(11):1173-81
pubmed: 17976010
J Assist Reprod Genet. 1998 Nov;15(10):612-8
pubmed: 9866071
PLoS One. 2011;6(11):e26877
pubmed: 22073213
J Immunol. 2000 Jun 15;164(12):6166-73
pubmed: 10843666
Cancer Res. 2005 Apr 15;65(8):3437-46
pubmed: 15833879
Blood. 2006 Jun 15;107(12):4930-7
pubmed: 16497970
Hum Reprod. 1998 Dec;13(12):3469-77
pubmed: 9886535
J Reprod Immunol. 2004 Apr;61(2):79-86
pubmed: 15063631
Front Immunol. 2017 Feb 09;8:120
pubmed: 28232836
Biol Reprod. 2004 Jun;70(6):1562-72
pubmed: 14766730
J Reprod Immunol. 2005 Oct;67(1-2):21-34
pubmed: 16107277
J Leukoc Biol. 2009 Jan;85(1):4-19
pubmed: 18784344
Placenta. 1999 Mar-Apr;20(2-3):229-33
pubmed: 10195746
J Clin Invest. 2005 Jan;115(1):56-65
pubmed: 15630444
Reproduction. 2002 Mar;123(3):379-87
pubmed: 11882015
Clin Exp Immunol. 2003 Mar;131(3):498-505
pubmed: 12605704
Baillieres Clin Obstet Gynaecol. 1991 Mar;5(1):25-59
pubmed: 1855342
Am J Reprod Immunol. 2016 Mar;75(3):298-309
pubmed: 26750089
Biol Reprod. 2012 Feb 14;86(2):39
pubmed: 22011391
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3378-83
pubmed: 17360654
Eur J Immunol. 2000 Jun;30(6):1623-31
pubmed: 10898498
Mol Hum Reprod. 2005 Dec;11(12):865-70
pubmed: 16421220
J Immunol. 1996 Jan 1;156(1):1-4
pubmed: 8598448
Reproduction. 2001 Nov;122(5):665-76
pubmed: 11690526
J Clin Invest. 2008 Dec;118(12):3954-65
pubmed: 19033665
Hum Reprod Update. 1996 Jul-Aug;2(4):307-21
pubmed: 9080228
FASEB J. 2005 Mar;19(3):311-30
pubmed: 15746175
Adv Drug Deliv Rev. 2004 Apr 29;56(8):1205-17
pubmed: 15094216
J Reprod Immunol. 2011 Dec;92(1-2):97-102
pubmed: 22015003
Hum Reprod Update. 2007 Jan-Feb;13(1):77-86
pubmed: 16960016
Endocrinology. 2002 Apr;143(4):1413-22
pubmed: 11897698
Exp Cell Res. 1999 Nov 25;253(1):117-30
pubmed: 10579917
J Leukoc Biol. 2004 Sep;76(3):509-13
pubmed: 15218057
Biol Reprod. 2003 Oct;69(4):1438-46
pubmed: 12826583
J Virol. 2015 Jan 15;89(2):1329-39
pubmed: 25392215
Am J Reprod Immunol. 2002 Jul;48(1):18-26
pubmed: 12322892
J Leukoc Biol. 2013 Feb;93(2):217-25
pubmed: 23108100
Cell. 2007 Aug 24;130(4):591-2
pubmed: 17719536
Hum Reprod Update. 2007 Mar-Apr;13(2):121-41
pubmed: 17068222
Cell. 2007 Aug 24;130(4):691-703
pubmed: 17719546
Hum Reprod. 2014 Jan;29(1):8-17
pubmed: 24140594
Cell. 1992 Oct 30;71(3):355-7
pubmed: 1423599
Am J Pathol. 2002 Apr;160(4):1405-23
pubmed: 11943725
Int Immunopharmacol. 2011 Oct;11(10):1442-50
pubmed: 21586343
Blood. 2005 Sep 1;106(5):1590-600
pubmed: 15914556
Hum Reprod. 2005 Dec;20(12):3518-25
pubmed: 16085663
J Immunol. 2013 Oct 1;191(7):3651-62
pubmed: 23997222
Rev Reprod. 2000 Jan;5(1):12-7
pubmed: 10711731
Clin Exp Immunol. 2005 Dec;142(3):481-9
pubmed: 16297160
J Exp Med. 2008 Jun 9;205(6):1261-8
pubmed: 18490490
J Reprod Immunol. 2006 Dec;72(1-2):18-32
pubmed: 16806485
J Reprod Immunol. 2002 Jul-Aug;56(1-2):3-17
pubmed: 12106880
J Leukoc Biol. 2003 Feb;73(2):209-12
pubmed: 12554797
J Matern Fetal Neonatal Med. 2003 Jan;13(1):39-44
pubmed: 12710855
Matrix Biol. 2002 Aug;21(5):441-8
pubmed: 12225809