Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine.
artificial intelligence
big data
cancer
nanotechnology
precision medicine
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
29
03
2019
revised:
17
05
2019
pubmed:
10
7
2019
medline:
31
12
2020
entrez:
10
7
2019
Statut:
ppublish
Résumé
Artificial intelligence (AI) and nanotechnology are two fields that are instrumental in realizing the goal of precision medicine-tailoring the best treatment for each cancer patient. Recent conversion between these two fields is enabling better patient data acquisition and improved design of nanomaterials for precision cancer medicine. Diagnostic nanomaterials are used to assemble a patient-specific disease profile, which is then leveraged, through a set of therapeutic nanotechnologies, to improve the treatment outcome. However, high intratumor and interpatient heterogeneities make the rational design of diagnostic and therapeutic platforms, and analysis of their output, extremely difficult. Integration of AI approaches can bridge this gap, using pattern analysis and classification algorithms for improved diagnostic and therapeutic accuracy. Nanomedicine design also benefits from the application of AI, by optimizing material properties according to predicted interactions with the target drug, biological fluids, immune system, vasculature, and cell membranes, all affecting therapeutic efficacy. Here, fundamental concepts in AI are described and the contributions and promise of nanotechnology coupled with AI to the future of precision cancer medicine are reviewed.
Identifiants
pubmed: 31286573
doi: 10.1002/adma.201901989
pmc: PMC7124889
mid: EMS83796
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1901989Subventions
Organisme : Israel Science Foundation
ID : 1421/17
Organisme : Unger Family Fund
Organisme : European Union FP-7 IRG Program for a Career Integration
ID : 908049
Organisme : Israel Science Foundation
ID : 1778/13
Organisme : Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology
Organisme : German-Israeli Foundation for Scientific Research and Development
ID : I-2328-1139.10/2012
Organisme : Lorry I. Lokey Interdisciplinary Center for Life Sciences & Engineering
Organisme : Mallat Family Foundation
Organisme : Ministry of Science and Technology, Israel
ID : 3-11878
Organisme : Phospholipid Research Center
Organisme : German-Israeli Foundation for Scientific Research and Development for a GIF Young
ID : I-2328-1139.10/2012
Organisme : Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion-Israel Institute of Technology
Organisme : FP7 Science in Society
ID : 908049
Organisme : ERC
ID : STG-2015-680242
Organisme : Israel Ministry of Economy for a Kamin
ID : 52752
Organisme : Technion Integrated Cancer Center
Organisme : European Research Council
ID : 680242
Pays : International
Organisme : Russell Berrie Nanotechnology Institute
Organisme : Israel Cancer Association
ID : 2015-0116
Organisme : Ministry of Economy
ID : 52752
Organisme : Israel Ministry of Science Technology and Space - Office of the Chief Scientist
ID : 3-11878
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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