Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins.
CRISPR
autophagy
cell biology
immunology
inflammation
macrophage
mouse
necroptosis
signaling
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 07 2019
09 07 2019
Historique:
received:
17
12
2018
accepted:
14
06
2019
entrez:
10
7
2019
pubmed:
10
7
2019
medline:
19
2
2020
Statut:
epublish
Résumé
RIPK1, RIPK3, ZBP1 and TRIF, the four mammalian proteins harboring RIP homotypic interaction motif (RHIM) domains, are key components of inflammatory signaling and programmed cell death. RHIM-domain protein activation is mediated by their oligomerization; however, mechanisms that promote a return to homeostasis remain unknown. Here we show that autophagy is critical for the turnover of all RHIM-domain proteins. Macrophages lacking the autophagy gene
Identifiants
pubmed: 31287416
doi: 10.7554/eLife.44452
pii: 44452
pmc: PMC6615860
doi:
pii:
Substances chimiques
Adaptor Proteins, Vesicular Transport
0
RNA-Binding Proteins
0
TICAM-1 protein, mouse
0
Zbp1 protein, mouse
0
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Ripk1 protein, mouse
EC 2.7.11.1
Ripk3 protein, mouse
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019, Lim et al.
Déclaration de conflit d'intérêts
JL, HP, JH, TM, MR, MX, BM, Mv, KN, AM Affiliated with Genentech. No other competing interests to declare
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