Fluctuations of sensorimotor processing in migraine: a controlled longitudinal study of beta event related desynchronization.
Cortex
Cycle
EEG
ERD
Headache
Migraine
Neurophysiology
Pathophysiology
Pre-activation
Thalamus
Journal
The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562
Informations de publication
Date de publication:
09 Jul 2019
09 Jul 2019
Historique:
received:
24
01
2019
accepted:
17
06
2019
entrez:
11
7
2019
pubmed:
11
7
2019
medline:
17
10
2019
Statut:
epublish
Résumé
The migraine brain seems to undergo cyclic fluctuations of sensory processing. For instance, during the preictal phase, migraineurs experience symptoms and signs of altered pain perception as well as other well-known premonitory CNS-symptoms. In the present study we measured EEG-activation to non-painful motor and sensorimotor tasks in the different phases of the migraine cycle by longitudinal measurements of beta event related desynchronization (beta-ERD). We recorded electroencephalography (EEG) of 41 migraine patients and 31 healthy controls. Each subject underwent three EEG recordings on three different days with classification of each EEG recording according to the actual migraine phase. During each recording, subjects performed one motor and one sensorimotor task with the flexion-extension movement of the right wrist. Migraine patients had significantly increased beta-ERD and higher baseline beta power at the contralateral C3 electrode overlying the primary sensorimotor cortex in the preictal phase compared to the interictal phase. We found no significant differences in beta-ERD or baseline beta power between interictal migraineurs and controls. Increased preictal baseline beta activity may reflect a decrease in pre-activation in the sensorimotor cortex. Altered pre-activation may lead to changes in thresholds for inhibitory responses and increased beta-ERD response, possibly reflecting a generally increased preictal cortical responsivity in migraine. Cyclic fluctuations in the activity of second- and third-order afferent somatosensory neurons, and their associated cortical and/or thalamic interneurons, may accordingly also be a central part of the migraine pathophysiology.
Sections du résumé
BACKGROUND
BACKGROUND
The migraine brain seems to undergo cyclic fluctuations of sensory processing. For instance, during the preictal phase, migraineurs experience symptoms and signs of altered pain perception as well as other well-known premonitory CNS-symptoms. In the present study we measured EEG-activation to non-painful motor and sensorimotor tasks in the different phases of the migraine cycle by longitudinal measurements of beta event related desynchronization (beta-ERD).
METHODS
METHODS
We recorded electroencephalography (EEG) of 41 migraine patients and 31 healthy controls. Each subject underwent three EEG recordings on three different days with classification of each EEG recording according to the actual migraine phase. During each recording, subjects performed one motor and one sensorimotor task with the flexion-extension movement of the right wrist.
RESULTS
RESULTS
Migraine patients had significantly increased beta-ERD and higher baseline beta power at the contralateral C3 electrode overlying the primary sensorimotor cortex in the preictal phase compared to the interictal phase. We found no significant differences in beta-ERD or baseline beta power between interictal migraineurs and controls.
CONCLUSION
CONCLUSIONS
Increased preictal baseline beta activity may reflect a decrease in pre-activation in the sensorimotor cortex. Altered pre-activation may lead to changes in thresholds for inhibitory responses and increased beta-ERD response, possibly reflecting a generally increased preictal cortical responsivity in migraine. Cyclic fluctuations in the activity of second- and third-order afferent somatosensory neurons, and their associated cortical and/or thalamic interneurons, may accordingly also be a central part of the migraine pathophysiology.
Identifiants
pubmed: 31288756
doi: 10.1186/s10194-019-1026-8
pii: 10.1186/s10194-019-1026-8
pmc: PMC6734210
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
77Références
Funct Neurol. 1999 Apr-Jun;14(2):69-77
pubmed: 10399619
Clin Neurophysiol. 1999 Nov;110(11):1842-57
pubmed: 10576479
Electroencephalogr Clin Neurophysiol Suppl. 1999;52:3-6
pubmed: 10590970
Neurosci Lett. 2000 May 26;286(1):66-8
pubmed: 10822154
Cephalalgia. 2000 Oct;20(8):714-9
pubmed: 11167900
Cephalalgia. 2001 Feb;21(1):31-7
pubmed: 11298661
Vision Res. 2001;41(10-11):1257-60
pubmed: 11322970
Clin Neurophysiol. 2001 Nov;112(11):2084-97
pubmed: 11682347
Neurology. 2003 Mar 25;60(6):935-40
pubmed: 12654956
J Clin Neurophysiol. 2004 Mar-Apr;21(2):99-104
pubmed: 15284600
Biol Cybern. 2005 Feb;92(2):101-9
pubmed: 15685391
Brain. 2006 Mar;129(Pt 3):695-706
pubmed: 16364953
Clin Neurophysiol. 2006 Mar;117(3):628-36
pubmed: 16427358
Neurosci Lett. 2006 May 29;400(1-2):121-4
pubmed: 16540242
Cephalalgia. 2006 Sep;26(9):1051-60
pubmed: 16919055
Prog Brain Res. 2006;159:211-22
pubmed: 17071233
Clin Neurophysiol. 2007 Aug;118(8):1877-88
pubmed: 17574912
Cephalalgia. 2007 Dec;27(12):1427-39
pubmed: 18034686
Cephalalgia. 2007 Dec;27(12):1454-6
pubmed: 18034689
Clin Neurophysiol. 2008 May;119(5):1020-7
pubmed: 18308628
Cephalalgia. 2008 Sep;28(9):960-8
pubmed: 18624805
Eur J Neurol. 2008 Nov;15(11):1199-205
pubmed: 18795945
Clin Neurophysiol. 2009 Mar;120(3):464-71
pubmed: 19157973
J Headache Pain. 2009 Oct;10(5):331-9
pubmed: 19705061
Cephalalgia. 2010 May;30(5):639; author reply 639-40
pubmed: 20511202
Ann Neurol. 2010 Jul;68(1):81-91
pubmed: 20582997
Cephalalgia. 2011 Mar;31(4):444-55
pubmed: 21098109
Acta Neurol Scand Suppl. 2011;(191):56-63
pubmed: 21711258
Eur J Neurosci. 2012 Jul;36(1):2088-97
pubmed: 22583034
Clin Neurophysiol. 2013 Jan;124(1):154-63
pubmed: 22819596
Headache. 2013 Jul-Aug;53(7):1071-86
pubmed: 23298223
Brain. 2014 Jan;137(Pt 1):232-41
pubmed: 24277718
Eur J Neurol. 1995 Apr;2(2):115-22
pubmed: 24283611
Clin Neurophysiol. 2014 Aug;125(8):1689-99
pubmed: 24457137
Nat Rev Neurol. 2014 Mar;10(3):144-55
pubmed: 24535465
Pain. 2014 Jun;155(6):1070-8
pubmed: 24631596
J Neuroeng Rehabil. 2014 May 30;11:90
pubmed: 24886610
Clin Neurophysiol. 2014 Sep;125(9):1721-30
pubmed: 24910147
J Neurosci. 2015 Jan 28;35(4):1627-37
pubmed: 25632138
Neuroscience. 2015 Jun 25;297:58-67
pubmed: 25839147
Headache. 2015 May;55(5):609-20
pubmed: 25919990
Clin Neurophysiol. 2016 Jan;127(1):810-816
pubmed: 26093935
Cephalalgia. 2016 May;36(6):568-78
pubmed: 26442930
Cephalalgia. 2016 Sep;36(10):951-9
pubmed: 26643378
Brain. 2016 Jul;139(Pt 7):1987-93
pubmed: 27190019
Cephalalgia. 2017 Sep;37(10):915-926
pubmed: 27358281
Cephalalgia. 2017 Oct;37(11):1082-1087
pubmed: 27821640
Cephalalgia. 2017 Dec;37(14):1337-1349
pubmed: 27919023
Neuroimage. 2017 Feb 15;147:175-185
pubmed: 27965146
Physiol Rev. 2017 Apr;97(2):553-622
pubmed: 28179394
Cephalalgia. 2018 Apr;38(4):718-729
pubmed: 28478712
Neuroimage. 2017 Oct 1;159:248-260
pubmed: 28756240
Cephalalgia. 2018 Jun;38(7):1237-1244
pubmed: 28853611
Hum Brain Mapp. 2018 Jun;39(6):2651-2663
pubmed: 29498776
Cephalalgia. 2018 Aug 4;:333102418791595
pubmed: 30079744
Cephalalgia. 2019 Apr;39(5):585-596
pubmed: 30099953
Pain. 2018 Nov;159(11):2414-2416
pubmed: 30335724
J Neurosci. 2018 Dec 5;38(49):10479-10488
pubmed: 30341182
Nat Rev Neurol. 2018 Dec;14(12):699-710
pubmed: 30448858
Electroencephalogr Clin Neurophysiol. 1995 May;94(5):381-4
pubmed: 7774524
Biol Psychiatry. 1993 Feb 1;33(3):173-87
pubmed: 8383545
Biomed Pharmacother. 1996;50(2):71-8
pubmed: 8761712
Brain Res Cogn Brain Res. 1996 Oct;4(3):171-83
pubmed: 8924046
Exp Brain Res. 1996 Dec;112(3):381-91
pubmed: 9007540
Electroencephalogr Clin Neurophysiol. 1997 May;104(3):199-206
pubmed: 9186234