Dynamic Interplay between miRNAs and the Extracellular Matrix Influences the Tumor Microenvironment.
cancer
estrogen receptors
extracellular matrix
miRNA-guided diagnostics
miRNAs
remodeling
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
16
03
2019
revised:
11
06
2019
accepted:
12
06
2019
pubmed:
11
7
2019
medline:
25
7
2020
entrez:
11
7
2019
Statut:
ppublish
Résumé
Expression of miRNAs is critical for the regulation of several cell functions including proliferation, migration, differentiation, and survival, as well as extracellular matrix (ECM) remodeling. The dynamic interplay between miRNAs, ECM macromolecules, and the tumor microenvironment plays critical roles in many aspects of human diseases such as metabolic disorders and cancers. Circulating and secreted miRNAs, via membrane vesicles, affect cell-cell communication and cellular metabolic pathways, underscoring their significance in tumor progression. The primary goal of this article is to highlight the importance of epigenetic regulatory factors, focusing on miRNA-mediated ECM reorganization and their functional relationships, and how matrix-mediated miRNAs affect tumor progression.
Identifiants
pubmed: 31288968
pii: S0968-0004(19)30140-9
doi: 10.1016/j.tibs.2019.06.007
pii:
doi:
Substances chimiques
Circulating MicroRNA
0
RNA, Neoplasm
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1076-1088Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.