Evaluating the effectiveness and cost-effectiveness of health facility-based and community-based index-linked HIV testing strategies for children: protocol for the B-GAP study in Zimbabwe.
adolescents
children
community
index-linked testing
oral mucosal HIV test
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
09 07 2019
09 07 2019
Historique:
entrez:
11
7
2019
pubmed:
11
7
2019
medline:
6
6
2020
Statut:
epublish
Résumé
The number of new paediatric infections per year has declined in sub-Saharan Africa due to prevention-of-mother-to-child HIV transmission programmes; many children and adolescents living with HIV remain undiagnosed. In this protocol paper, we describe the methodology for evaluating an index-linked HIV testing approach for children aged 2-18 years in health facility and community settings in Zimbabwe. Individuals attending for HIV care at selected primary healthcare clinics (PHCs) will be asked if they have any children aged 2-18 years in their households who have not been tested for HIV. Three options for HIV testing for these children will be offered: testing at the PHC; home-based testing performed by community workers; or an oral mucosal HIV test given to the caregiver to test the children at home. All eligible children will be followed-up to ascertain whether HIV testing occurred. For those who did not test, reasons will be determined, and for those who tested, the HIV test result will be recorded. The primary outcome will be uptake of HIV testing. The secondary outcomes will be preferred HIV testing method, HIV yield, prevalence and proportion of those testing positive linking to care and having an undetectable viral load at 12 months. HIV test results will be stratified by sex and age group, and factors associated with uptake of HIV testing and choice of HIV testing method will be investigated. Ethical approval for this study was granted by the Medical Research Council of Zimbabwe, the London School of Hygiene and Tropical Medicine and the Institutional Review Board of the Biomedical Research and Training Institute. Study results will be presented at national policy meetings and national and international research conferences. Results will also be published in international peer-reviewed scientific journals and disseminated to study communities at the end of study.
Identifiants
pubmed: 31289091
pii: bmjopen-2019-029428
doi: 10.1136/bmjopen-2019-029428
pmc: PMC6615786
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e029428Subventions
Organisme : FIC NIH HHS
ID : D43 TW009539
Pays : United States
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P011268/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206316/Z/17/Z
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
PLoS Med. 2017 Jul 25;14(7):e1002360
pubmed: 28742829
Lancet Child Adolesc Health. 2017 Nov;1(3):175-183
pubmed: 29104904
Pharmacoeconomics. 2018 May;36(5):509-522
pubmed: 29427072
J Int AIDS Soc. 2017 Nov;20 Suppl 7:
pubmed: 29171193
Curr Opin HIV AIDS. 2018 May;13(3):257-264
pubmed: 29401121
Clin Infect Dis. 2010 Oct 1;51(7):844-51
pubmed: 20804412
Lancet HIV. 2015 Apr;2(4):e159-68
pubmed: 25844394
Open AIDS J. 2016 Apr 08;10:34-48
pubmed: 27347270
PLoS Med. 2010 Jul 20;7(7):e1000285
pubmed: 20652012
AIDS Care. 2010 Nov;22(11):1346-9
pubmed: 20635242
PLoS One. 2016 Jun 09;11(6):e0155510
pubmed: 27280282
J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):e83-e89
pubmed: 27846074
Trop Med Int Health. 2017 Aug;22(8):1021-1029
pubmed: 28544728
BMJ. 2015 Mar 19;350:h1258
pubmed: 25791983
Lancet HIV. 2016 Oct;3(10):e473-81
pubmed: 27658876