Mechanisms of lipid droplet biogenesis.
endoplasmic reticulum
lipid droplets
lipid metabolism
organelle biogenesis
plant biology
triglycerides
Journal
The Biochemical journal
ISSN: 1470-8728
Titre abrégé: Biochem J
Pays: England
ID NLM: 2984726R
Informations de publication
Date de publication:
09 07 2019
09 07 2019
Historique:
received:
03
05
2019
revised:
11
06
2019
accepted:
13
06
2019
entrez:
11
7
2019
pubmed:
11
7
2019
medline:
19
3
2020
Statut:
epublish
Résumé
Lipid droplets (LDs) are organelles that compartmentalize nonbilayer-forming lipids in the aqueous cytoplasm of cells. They are ubiquitous in most organisms, including in animals, protists, plants and microorganisms. In eukaryotes, LDs are believed to be derived by a budding and scission process from the surface of the endoplasmic reticulum, and this occurs concomitantly with the accumulation of neutral lipids, most often triacylglycerols and steryl esters. Overall, the mechanisms underlying LD biogenesis are difficult to generalize, in part because of the involvement of different sets of both evolutionarily conserved and organism-specific LD-packaging proteins. Here, we briefly compare and contrast these proteins and the allied processes responsible for LD biogenesis in cells of animals, yeasts and plants.
Identifiants
pubmed: 31289128
pii: BCJ20180021
doi: 10.1042/BCJ20180021
doi:
Substances chimiques
Triglycerides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1929-1942Informations de copyright
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.