YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
Animals
Body Temperature
COP-Coated Vesicles
/ genetics
Diet, High-Fat
/ adverse effects
Endoplasmic Reticulum
/ genetics
Energy Metabolism
/ genetics
Fibroblast Growth Factors
/ blood
Gene Expression Regulation
Hepatocytes
/ metabolism
Humans
Lipolysis
/ genetics
Liver
/ metabolism
Membrane Proteins
/ genetics
Metabolic Syndrome
/ etiology
Mice
Mice, Knockout
Non-alcoholic Fatty Liver Disease
/ genetics
Obesity
/ etiology
Protein Binding
Signal Transduction
Thermogenesis
/ genetics
Vesicular Transport Proteins
/ genetics
COPII vesicles
FGF21
YIPF6
obesity
sorting receptor
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
23 07 2019
23 07 2019
Historique:
pubmed:
11
7
2019
medline:
31
3
2020
entrez:
11
7
2019
Statut:
ppublish
Résumé
Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates glucose, lipid, and energy homeostasis. While gene expression of FGF21 is regulated by the nuclear hormone receptor peroxisome proliferator-activated receptor alpha in the fasted state, little is known about the regulation of trafficking and secretion of FGF21. We show that mice with a mutation in the Yip1 domain family, member 6 gene (
Identifiants
pubmed: 31289229
pii: 1904360116
doi: 10.1073/pnas.1904360116
pmc: PMC6660779
doi:
Substances chimiques
Membrane Proteins
0
Vesicular Transport Proteins
0
YIPF6 protein, human
0
Yipf6 protein, mouse
0
fibroblast growth factor 21
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15184-15193Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL105278
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010337
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK057978
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK076906
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA020703
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest statement: B.B. received salary support from Pfizer, Inc. B.S. is consulting for Ferring Research Institute.
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