Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 07 2019
09 07 2019
Historique:
received:
06
03
2019
accepted:
17
06
2019
entrez:
11
7
2019
pubmed:
11
7
2019
medline:
28
10
2020
Statut:
epublish
Résumé
Over the course of a mission to the International Space Station (ISS) crew members are exposed to a number of stressors that can potentially alter the composition of their microbiomes and may have a negative impact on astronauts' health. Here we investigated the impact of long-term space exploration on the microbiome of nine astronauts that spent six to twelve months in the ISS. We present evidence showing that the microbial communities of the gastrointestinal tract, skin, nose and tongue change during the space mission. The composition of the intestinal microbiota became more similar across astronauts in space, mostly due to a drop in the abundance of a few bacterial taxa, some of which were also correlated with changes in the cytokine profile of crewmembers. Alterations in the skin microbiome that might contribute to the high frequency of skin rashes/hypersensitivity episodes experienced by astronauts in space were also observed. The results from this study demonstrate that the composition of the astronauts' microbiome is altered during space travel. The impact of those changes on crew health warrants further investigation before humans embark on long-duration voyages into outer space.
Identifiants
pubmed: 31289321
doi: 10.1038/s41598-019-46303-8
pii: 10.1038/s41598-019-46303-8
pmc: PMC6616552
doi:
Substances chimiques
Cytokines
0
DNA, Bacterial
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
9911Références
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