Transcriptional suppression of the miR-15/16 family by c-Myc in malignant pleural mesothelioma.
c-MYC
mesothelioma
microRNA
transcriptional repression
tumor suppressor
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
25 Jun 2019
25 Jun 2019
Historique:
received:
12
02
2019
accepted:
04
05
2019
entrez:
11
7
2019
pubmed:
11
7
2019
medline:
11
7
2019
Statut:
epublish
Résumé
MicroRNA downregulation is frequent in malignant pleural mesothelioma (MPM), but the mechanisms responsible for loss of miR-15/16 and miR-193a are yet to be elucidated and were investigated in this study. Copy Number Variation (CNV) of microRNA-coding genes was analyzed in MPM cells by digital droplet PCR (ddPCR) and revealed heterozygous loss of miR-193a and miR-15a/16-1, but no change in miR-15b/16-2. Epigenetic control of microRNA expression was inferred following decitabine and Trichostatin A (TSA) treatment which did not substantially affect microRNA expression. Knockdown of c-Myc expression led to upregulation of
Identifiants
pubmed: 31289611
doi: 10.18632/oncotarget.27010
pii: 27010
pmc: PMC6609241
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4125-4138Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors declare that they have no conflicts of interests.
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