Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women: Results from the EPIC Cohort.
Age Factors
Biomarkers
/ blood
Body Mass Index
Contraception Behavior
/ statistics & numerical data
Cross-Sectional Studies
Estrogen Replacement Therapy
/ statistics & numerical data
Female
Humans
Life Style
Middle Aged
Osteoprotegerin
/ blood
Postmenopause
/ blood
Premenopause
/ blood
RANK Ligand
/ blood
Reproductive History
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
08
03
2019
revised:
06
05
2019
accepted:
03
07
2019
pubmed:
12
7
2019
medline:
25
9
2020
entrez:
12
7
2019
Statut:
ppublish
Résumé
Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator of Nuclear Factor κB (sRANKL) and OPG concentrations in women are limited. We evaluated reproductive and lifestyle factors as potential sources of variation in circulating sRANKL and OPG concentrations in pre- and postmenopausal women. This study includes 2,016 controls [ Older age at blood collection was associated with lower sRANKL concentrations in postmenopausal women ( Circulating sRANKL and OPG concentrations are minimally impacted by hormone-related factors in pre- and postmenopausal women. This study suggests circulating concentrations of sRANKL and OPG are unlikely to be strongly modified by hormone-related reproductive and lifestyle factors.
Sections du résumé
BACKGROUND
Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator of Nuclear Factor κB (sRANKL) and OPG concentrations in women are limited. We evaluated reproductive and lifestyle factors as potential sources of variation in circulating sRANKL and OPG concentrations in pre- and postmenopausal women.
METHODS
This study includes 2,016 controls [
RESULTS
Older age at blood collection was associated with lower sRANKL concentrations in postmenopausal women (
CONCLUSIONS
Circulating sRANKL and OPG concentrations are minimally impacted by hormone-related factors in pre- and postmenopausal women.
IMPACT
This study suggests circulating concentrations of sRANKL and OPG are unlikely to be strongly modified by hormone-related reproductive and lifestyle factors.
Identifiants
pubmed: 31292137
pii: 1055-9965.EPI-19-0241
doi: 10.1158/1055-9965.EPI-19-0241
doi:
Substances chimiques
Biomarkers
0
Osteoprotegerin
0
RANK Ligand
0
TNFRSF11B protein, human
0
TNFSF11 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1746-1754Subventions
Organisme : Cancer Research UK
ID : C8221/A19170
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom
Organisme : Medical Research Council
ID : 1000143
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M012190/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C570/A16491
Pays : United Kingdom
Informations de copyright
©2019 American Association for Cancer Research.