Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1β Maturation and ASC Speck Formation in Macrophages.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
30
05
2018
accepted:
15
06
2019
pubmed:
12
7
2019
medline:
10
4
2020
entrez:
12
7
2019
Statut:
ppublish
Résumé
Protein arginine deiminase (PAD) enzymes catalyze the conversion of protein-bound arginine into citrulline, an irreversible posttranslational modification with loss of a positive charge that can influence protein-protein interactions and protein structure. Protein arginine deiminase activity depends on high intracellular calcium concentrations occurring in dying cells. In this study, we demonstrate that protein citrullination is common during pyroptotic cell death in macrophages and that inhibition of PAD enzyme activity by Cl-amidine, a pan-PAD inhibitor, blocks NLRP3 inflammasome assembly and proinflammatory IL-1β release in macrophages. Genetic deficiency of either PAD2 or PAD4 alone in murine macrophages does not impair IL-1β release; however, pharmacological inhibition or small interfering RNA knockdown of PAD2 within PAD4
Identifiants
pubmed: 31292215
pii: jimmunol.1800720
doi: 10.4049/jimmunol.1800720
pmc: PMC6690178
mid: NIHMS1044765
doi:
Substances chimiques
CARD Signaling Adaptor Proteins
0
Inflammasomes
0
Interleukin-1beta
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Protein-Arginine Deiminases
EC 3.5.3.15
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
795-800Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118112
Pays : United States
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
Références
Bioessays. 2003 Nov;25(11):1106-18
pubmed: 14579251
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Ann Rheum Dis. 2004 Apr;63(4):373-81
pubmed: 15020330
Anal Biochem. 1992 May 15;203(1):94-100
pubmed: 1524220
J Biol Chem. 2007 Jan 26;282(4):2386-94
pubmed: 17121814
Mol Cell. 2007 Aug 17;27(4):622-35
pubmed: 17707233
Arthritis Rheum. 2007 Nov;56(11):3541-53
pubmed: 17968929
J Immunol. 2008 Feb 1;180(3):1895-902
pubmed: 18209087
Nature. 2009 Mar 26;458(7237):514-8
pubmed: 19158675
J Immunol. 2009 Jul 15;183(2):787-91
pubmed: 19570822
Nat Immunol. 2010 May;11(5):395-402
pubmed: 20351692
J Exp Med. 2010 Aug 30;207(9):1853-62
pubmed: 20733033
Sci Transl Med. 2011 Mar 9;3(73):73ra19
pubmed: 21389263
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11282-7
pubmed: 22733741
Nature. 2012 Dec 6;492(7427):123-7
pubmed: 23143333
Nat Commun. 2012;3:1329
pubmed: 23271661
Sci Transl Med. 2013 Mar 27;5(178):178ra40
pubmed: 23536012
Nat Rev Immunol. 2013 Jun;13(6):397-411
pubmed: 23702978
Immunity. 2013 Jun 27;38(6):1142-53
pubmed: 23809161
Ann Rheum Dis. 2015 Nov;74(11):2062-9
pubmed: 24914072
Nat Chem Biol. 2015 Mar;11(3):189-91
pubmed: 25622091
Nat Med. 2015 Mar;21(3):248-55
pubmed: 25686105
Nat Commun. 2015 Mar 12;6:6574
pubmed: 25762200
J Immunol. 2015 Apr 15;194(8):3937-52
pubmed: 25762778
Mediators Inflamm. 2015;2015:236451
pubmed: 26078491
Nat Immunol. 2016 Mar;17(3):250-8
pubmed: 26642356
Sci Adv. 2016 Feb 05;2(2):e1501257
pubmed: 26989780
Cell Mol Immunol. 2017 Jan;14(1):65-79
pubmed: 27345727
J Biol Chem. 1989 Oct 25;264(30):18119-27
pubmed: 2808368
J Med Chem. 2017 Apr 13;60(7):3198-3211
pubmed: 28328217
AIDS. 2018 Jan 28;32(3):299-307
pubmed: 29135573
J Biochem. 1981 Jan;89(1):257-63
pubmed: 7217033
Biochem Biophys Res Commun. 1998 Feb 24;243(3):641-6
pubmed: 9500980