Rheumatoid Arthritis Complicated with Nasal Septum Perforation Due to Methotrexate-associated Lymphoproliferative Disorder.
Adult
Antibodies, Monoclonal, Humanized
/ therapeutic use
Antirheumatic Agents
/ adverse effects
Arthritis, Rheumatoid
/ complications
Biopsy
Diagnosis, Differential
Drug Therapy, Combination
Female
Humans
Lymph Nodes
/ pathology
Lymphoproliferative Disorders
/ chemically induced
Methotrexate
/ adverse effects
Nasal Septal Perforation
/ etiology
Nasal Septum
/ pathology
methotrexate-associated lymphoproliferative disorder
nasal septum perforation
peripheral T-cell lymphoma
rheumatoid arthritis
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Nov 2019
01 Nov 2019
Historique:
pubmed:
12
7
2019
medline:
12
2
2020
entrez:
12
7
2019
Statut:
ppublish
Résumé
A 44-year-old female with rheumatoid arthritis treated with methotrexate (MTX) and tocilizumab (TCZ) was admitted to our hospital with nasal pain. Nasal fiberscopy revealed septum perforation, while a membrane biopsy indicated granuloma and fibrinoid necrosis of the small artery. The patient was treated with prednisolone 30 mg/day after discontinuation of MTX and TCZ. Inguinal lymph node biopsy revealed diffuse infiltrations of atypical T-cells and Epstein-Barr virus-positive B cells. The patient was diagnosed with peripheral T-cell lymphoma due to MTX-associated lymphoproliferative disorder (MTX-LPD). We herein describe the case of a patient with nasal septum perforation due to MTX-LPD mimicking granulomatosis with polyangiitis.
Identifiants
pubmed: 31292392
doi: 10.2169/internalmedicine.2995-19
pmc: PMC6875446
doi:
Substances chimiques
Antibodies, Monoclonal, Humanized
0
Antirheumatic Agents
0
tocilizumab
I031V2H011
Methotrexate
YL5FZ2Y5U1
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3167-3171Références
Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(3):174-178
pubmed: 28747604
J Rheumatol. 1991 Nov;18(11):1741-3
pubmed: 1787499
Mod Rheumatol. 2017 Sep;27(5):773-777
pubmed: 27846761
Semin Arthritis Rheum. 1996 Oct;26(2):564-74
pubmed: 8916300
Rheumatology (Oxford). 2017 Jun 1;56(6):940-946
pubmed: 28165538
Am J Med. 1987 Apr;82(4):839-44
pubmed: 3494400
Ann Rheum Dis. 2006 Dec;65(12):1667-9
pubmed: 17105857
JAMA. 2012 Sep 5;308(9):898-908
pubmed: 22948700
PLoS One. 2017 Feb 15;12(2):e0171623
pubmed: 28199343
Leuk Lymphoma. 2012 Apr;53(4):616-23
pubmed: 21933041
Cancer. 1995 Mar 15;75(6):1281-91
pubmed: 7882278
Leuk Lymphoma. 2015;56(11):3045-51
pubmed: 25721751
Arthritis Care Res (Hoboken). 2014 Sep;66(9):1302-9
pubmed: 24515570
Eur J Haematol. 2013 Jul;91(1):20-8
pubmed: 23560463
Joint Bone Spine. 2016 Jul;83(4):412-5
pubmed: 26725744