Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine "Goreisan".
Adult
Aged
Aged, 80 and over
Antineoplastic Agents
/ adverse effects
Chylothorax
/ chemically induced
Dasatinib
/ adverse effects
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ drug therapy
Male
Medicine, Kampo
Middle Aged
Phytotherapy
Plant Extracts
/ therapeutic use
Pleural Effusion
/ chemically induced
Radiography, Thoracic
Goreisan
aquaporin
chronic myeloid leukemia
chylothorax
dasatinib
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Nov 2019
01 Nov 2019
Historique:
pubmed:
12
7
2019
medline:
12
2
2020
entrez:
12
7
2019
Statut:
ppublish
Résumé
Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine "Goreisan." "Goreisan" is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that "Goreisan" is an effective treatment option for uncontrollable dasatinib-related chylothorax.
Identifiants
pubmed: 31292394
doi: 10.2169/internalmedicine.3002-19
pmc: PMC6875454
doi:
Substances chimiques
Antineoplastic Agents
0
Plant Extracts
0
Dasatinib
RBZ1571X5H
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3139-3141Références
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