Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/β-catenin signaling in colorectal cancer cells.
Apoptosis
/ genetics
Carcinogenesis
/ genetics
Cell Line, Tumor
Colorectal Neoplasms
/ genetics
Down-Regulation
Gene Expression Regulation, Neoplastic
HCT116 Cells
HEK293 Cells
Humans
Interferon Regulatory Factor-1
/ metabolism
Nuclear Proteins
/ metabolism
Proteolysis
Ubiquitin-Specific Proteases
/ metabolism
Ubiquitination
/ genetics
Wnt Signaling Pathway
/ physiology
beta Catenin
/ metabolism
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
19
05
2018
accepted:
16
04
2019
revised:
27
02
2019
pubmed:
12
7
2019
medline:
29
1
2020
entrez:
12
7
2019
Statut:
ppublish
Résumé
Impaired Wnt signaling pathway plays a crucial role in the development of colorectal cancer through activation of the β-catenin/TCF7L2 complex. Although genes upregulated by Wnt/β-catenin signaling have been intensively studied, the roles of downregulated genes are poorly understood. Previously, we reported that interferon-induced proteins with tetratricopeptide repeats 2 (IFIT2) was downregulated by the Wnt/β-catenin signaling, and that the suppressed expression of IFIT2 conferred antiapoptotic property to colorectal cancer (CRC) cells. However, the mechanisms underlying how Wnt/β-catenin signaling regulates IFIT2 remain to be elucidated. In this study, we have uncovered that the expression of IFIT2 is induced by IRF1, which is negatively regulated by the Wnt/β-catenin signaling. In addition, we found that downregulation of IRF1 is mediated by its degradation through the ubiquitination-proteasome pathway, and that decreased activity of a deubiquitinase complex containing USP1 and UAF1 is involved in the degradation of IRF1 by Wnt/β-catenin signaling. These data should provide better understanding of the Wnt signaling pathway and human carcinogenesis.
Identifiants
pubmed: 31292489
doi: 10.1038/s41388-019-0856-9
pii: 10.1038/s41388-019-0856-9
doi:
Substances chimiques
IRF1 protein, human
0
Interferon Regulatory Factor-1
0
Nuclear Proteins
0
USP1 associated factor 1, human
0
beta Catenin
0
USP1 protein, human
EC 3.4.19.12
Ubiquitin-Specific Proteases
EC 3.4.19.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6051-6064Références
Biochem Biophys Res Commun. 1999 Apr 21;257(3):672-7
pubmed: 10208842
Oncogene. 2013 Jan 24;32(4):471-8
pubmed: 22391563
J Biol Chem. 2012 Aug 24;287(35):29429-41
pubmed: 22778262
Mol Cell. 2007 Dec 14;28(5):786-97
pubmed: 18082604
Nat Commun. 2014 Aug 27;5:4763
pubmed: 25159004
Oncogene. 2006 Jun 26;25(27):3787-800
pubmed: 16799620
Oncoimmunology. 2012 Nov 1;1(8):1376-1386
pubmed: 23243601
Structure. 2015 Nov 3;23(11):2043-54
pubmed: 26388029
Nat Cell Biol. 2006 Apr;8(4):339-47
pubmed: 16531995
J Biol Chem. 2009 Feb 20;284(8):5343-51
pubmed: 19075014
J Cell Biochem. 2002;85(2):369-80
pubmed: 11948692
Nat Genet. 2000 Mar;24(3):245-50
pubmed: 10700176
Mol Cell. 2007 Dec 14;28(5):798-809
pubmed: 18082605
Cancer Lett. 1994 Aug 15;83(1-2):191-6
pubmed: 8062214
Pancreas. 2014 Aug;43(6):909-16
pubmed: 24632547
Int J Oncol. 1998 Dec;13(6):1207-16
pubmed: 9824633
Nat Struct Mol Biol. 2016 Apr;23(4):270-7
pubmed: 26950370
J Biol Chem. 2004 May 7;279(19):19712-20
pubmed: 14993214
Biochem J. 2009 Mar 15;418(3):575-85
pubmed: 19032150
J Gastroenterol Hepatol. 2005 Mar;20(3):371-80
pubmed: 15740479
Neoplasia. 2007 Nov;9(11):951-9
pubmed: 18030363
Nature. 1995 Aug 17;376(6541):596-9
pubmed: 7637809
Biochim Biophys Acta. 2003 Jun 5;1653(1):1-24
pubmed: 12781368
Mol Cell. 2017 Jan 19;65(2):247-259
pubmed: 27986371
Int J Cancer. 2003 Apr 20;104(4):400-8
pubmed: 12584735
Cancer Lett. 2015 Apr 1;359(1):136-47
pubmed: 25592039
Cancer Res. 2001 Dec 15;61(24):8917-23
pubmed: 11751417
Nature. 2007 Apr 5;446(7136):676-9
pubmed: 17377531
Cancer Res. 1996 Feb 1;56(3):612-5
pubmed: 8564980
Int J Breast Cancer. 2011;2011:912102
pubmed: 22295238
J Clin Pathol. 2005 Mar;58(3):225-36
pubmed: 15735151
Cell. 1993 Oct 8;75(1):83-97
pubmed: 8402903
Cell Rep. 2016 Jun 7;15(10):2118-2126
pubmed: 27239033
Chem Biol. 2011 Nov 23;18(11):1390-400
pubmed: 22118673
Cancer Res. 1996 May 15;56(10):2417-21
pubmed: 8625321
Oncogene. 2000 Jul 13;19(30):3372-83
pubmed: 10918594
Mol Cancer Ther. 2013 Dec;12(12):2651-62
pubmed: 24130053
Immunity. 1997 Aug;7(2):243-54
pubmed: 9285409
Int J Cancer. 1998 Aug 12;77(4):522-7
pubmed: 9679752
Nature. 1999 Apr 1;398(6726):422-6
pubmed: 10201372
Nature. 2009 Mar 26;458(7237):438-44
pubmed: 19325623
Science. 1994 Jun 3;264(5164):1415-21
pubmed: 8197455
Science. 1993 Feb 12;259(5097):971-4
pubmed: 8438157
J Interferon Cytokine Res. 2005 Oct;25(10):587-94
pubmed: 16241857
Int J Mol Sci. 2017 Jul 25;18(8):
pubmed: 28757546
Oncogene. 2002 Nov 7;21(51):7776-85
pubmed: 12420214
Mol Cell Biol. 1987 Dec;7(12):4498-504
pubmed: 2830497
Oncogene. 1994 Nov;9(11):3313-20
pubmed: 7936656
Nature. 2007 Oct 25;449(7165):1003-7
pubmed: 17934449
Cancer Res. 1998 Mar 1;58(5):896-9
pubmed: 9500446
Mol Cell Biol. 2011 Jun;31(12):2462-9
pubmed: 21482670
Oncogene. 2003 Feb 20;22(7):1045-56
pubmed: 12592391
Cell Death Differ. 2010 Apr;17(4):699-709
pubmed: 19851330
Biochem J. 2013 Feb 1;449(3):707-17
pubmed: 23134341
Clin Cancer Res. 2001 May;7(5):1293-8
pubmed: 11350897
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Ann Surg Oncol. 1999 Sep;6(6):604-8
pubmed: 10493631
Br J Cancer. 2013 Jul 9;109(1):76-82
pubmed: 23807161
Oncotarget. 2017 Oct 26;8(59):100176-100186
pubmed: 29245969
EMBO J. 2004 Aug 4;23(15):3051-60
pubmed: 15241475
Genes Dev. 1999 May 15;13(10):1240-5
pubmed: 10346812
J Biol Chem. 2010 Apr 2;285(14):10362-9
pubmed: 20147293
Genes Dev. 2014 Jul 15;28(14):1517-32
pubmed: 25030692
Cytokine. 2004 May 21;26(4):164-8
pubmed: 15149633
Oncogene. 2004 Feb 5;23(5):1125-35
pubmed: 14762441
J Biol Chem. 2011 Jan 7;286(1):607-19
pubmed: 20947504
Cancer Res. 1998 Apr 1;58(7):1344-7
pubmed: 9537226
Cancer Res. 2007 Mar 15;67(6):2535-43
pubmed: 17363571
Eur J Cancer. 1998 Sep;34(10):1522-34
pubmed: 9893623