Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.

Aging / physiology Animals Cellular Senescence / physiology Esterases / antagonists & inhibitors Female Humans Intestinal Mucosa / pathology Male Mechanistic Target of Rapamycin Complex 1 / metabolism Mice PPAR alpha / metabolism Paneth Cells / metabolism Receptors, G-Protein-Coupled / metabolism Regeneration Stem Cell Niche Stem Cells / pathology Wnt Proteins / antagonists & inhibitors Wnt Signaling Pathway

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2019
Historique:
received: 12 04 2016
accepted: 10 06 2019
pubmed: 12 7 2019
medline: 8 10 2019
entrez: 12 7 2019
Statut: ppublish

Résumé

A decline in stem cell function impairs tissue regeneration during ageing, but the role of the stem-cell-supporting niche in ageing is not well understood. The small intestine is maintained by actively cycling intestinal stem cells that are regulated by the Paneth cell niche

Identifiants

DOI: 10.1038/s41586-019-1383-0 PMID: 31292548 PMC: PMC8151802
pubmed: 31292548
doi: 10.1038/s41586-019-1383-0
pii: 10.1038/s41586-019-1383-0
pmc: PMC8151802
mid: NIHMS1626400
doi:

Substances chimiques

Lgr5 protein, mouse 0
PPAR alpha 0
Receptors, G-Protein-Coupled 0
Wnt Proteins 0
Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1
Esterases EC 3.1.-
Notum protein, human EC 3.1.1.-
Notum protein, mouse EC 3.1.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

398-402

Subventions

Organisme : NIGMS NIH HHS
ID : T32 GM007287
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014051
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG045144
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA034992
Pays : United States

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Auteurs

Nalle Pentinmikko (N)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Sharif Iqbal (S)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Miyeko Mana (M)

The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.

Simon Andersson (S)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Armand B Cognetta (AB)

The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.

Radu M Suciu (RM)

The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.

Jatin Roper (J)

Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC, USA.

Kalle Luopajärvi (K)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Eino Markelin (E)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Swetha Gopalakrishnan (S)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Olli-Pekka Smolander (OP)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Santiago Naranjo (S)

The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.

Tuure Saarinen (T)

Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Abdominal Center, Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland.

Anne Juuti (A)

Abdominal Center, Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland.

Kirsi Pietiläinen (K)

Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.

Petri Auvinen (P)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.

Ari Ristimäki (A)

Department of Pathology, Research Programs Unit and HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Nitin Gupta (N)

Atlanta Gastroenterology Associates, Atlanta, GA, USA.

Tuomas Tammela (T)

Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tyler Jacks (T)

The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.
Howard Hughes Medical Institute, MIT, Cambridge, MA, USA.

David M Sabatini (DM)

The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.
Howard Hughes Medical Institute, MIT, Cambridge, MA, USA.
Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA, USA.

Benjamin F Cravatt (BF)

The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.

Ömer H Yilmaz (ÖH)

The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA, USA.

Pekka Katajisto (P)

Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.
Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. pekka.katajisto@helsinki.fi.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules de Paneth › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Niche de cellules souches › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Cellules › Cellules souches › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de type Wingless › Notum produced by Paneth cells attenuates...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Notum produced by Paneth cells attenuates...