Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation.
cytokine signaling
hematopoietic stem cell
thrombopoietin
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
28
03
2019
revised:
09
05
2019
accepted:
24
05
2019
pubmed:
12
7
2019
medline:
2
10
2020
entrez:
12
7
2019
Statut:
ppublish
Résumé
Thrombopoietin (Thpo) and its receptor myeloid proliferative leukemia (Mpl) were initially identified as the cytokine signaling that stimulates megakaryopoiesis and platelet production. However, Thpo-Mpl signaling has also been widely characterized as one of the few cytokine systems that directly regulates hematopoietic stem and progenitor cells. The ability of Thpo signaling to stimulate hematopoietic stem cell (HSC) self-renewal has led to the development and utilization of Thpo mimetic drugs to treat hematopoietic diseases with restricted function of HSCs, such as aplastic anemia. This review will cover the mechanisms by which Thpo-Mpl signaling regulates HSCs.
Substances chimiques
Receptors, Thrombopoietin
0
MPL protein, human
143641-95-6
Thrombopoietin
9014-42-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-58Informations de copyright
© 2019 New York Academy of Sciences.
Références
Kelemen, E., I. Cserháti & B. Tanos. 1958. Demonstration and some properties of human thrombopoietin in thrombocythaemic sera. Acta Haematol. 20: 350-355.
McDonald, T.P. 1988. Thrombopoietin: its biology, purification, and characterization. Exp. Hematol. 16: 201-205.
Vigon, I., C. Florindo, S. Fichelson, et al. 1993. Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene 8: 2607-2615.
Vigon, I., J.P. Mornon, L. Cocault, et al. 1992. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. USA 89: 5640-5644.
Methia, N., F. Louache, W. Vainchenker, et al. 1993. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82: 1395-1401.
Souyri, M., I. Vigon, J.F. Penciolelli, et al. 1990. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63: 1137-1147.
Lok, S., K. Kaushansky, R.D. Holly, et al. 1994. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369: 565-568.
Sohma, Y., H. Akahori, N. Seki, et al. 1994. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett. 353: 57-61.
Kuter, D.J., D.L. Beeler & R.D. Rosenberg. 1994. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc. Natl. Acad. Sci. USA 91: 11104-11108.
Kaushansky, K., S. Lok, R.D. Holly, et al. 1994. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369: 568-571.
Kaushansky, K. 1995. Thrombopoietin: the primary regulator of megakaryocyte and platelet production. Thromb. Haemost. 74: 521-525.
Hitchcock, I.S. & K. Kaushansky. 2014. Thrombopoietin from beginning to end. Br. J. Haematol. 165: 259-268.
Kaushansky, K., V.C. Broudy, N. Lin, et al. 1995. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proc. Natl. Acad. Sci. USA 92: 3234-3238.
Alexander, W.S., A.W. Roberts, N.A. Nicola, et al. 1996. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 87: 2162-2170.
Carver-Moore, K., H.E. Broxmeyer, S.M. Luoh, et al. 1996. Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood 88: 803-808.
Ku, H., Y. Yonemura, K. Kaushansky, et al. 1996. Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87: 4544-4551.
Sitnicka, E., N. Lin, G.V. Priestley, et al. 1996. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 87: 4998-5005.
Borge, O.J., V. Ramsfjell, O.P. Veiby, et al. 1996. Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. Blood 88: 2859-2870.
Ng, A.P., M. Kauppi, D. Metcalf, et al. 2012. Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential. Proc. Natl. Acad. Sci. USA 109: 2364-2369.
Qian, H., N. Buza-Vidas, C.D. Hyland, et al. 2007. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 1: 671-684.
Ballmaier, M. & M. Germeshausen. 2011. Congenital amegakaryocytic thrombocytopenia: clinical presentation, diagnosis, and treatment. Semin. Thromb. Hemost. 37: 673-681.
Kimura, S., A.W. Roberts, D. Metcalf, et al. 1998. Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc. Natl. Acad. Sci. USA 95: 1195-1200.
Abkowitz, J.L. & J. Chen. 2007. Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones. Blood 109: 5186-5190.
Walter, D., A. Lier, A. Geiselhart, et al. 2015. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature 520: 549-552.
Kovtonyuk, L.V., M.G. Manz & H. Takizawa. 2016. Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo. Blood 127: 3175-3179.
Nakamura-Ishizu, A., H. Takizawa & T. Suda. 2014. The analysis, roles and regulation of quiescence in hematopoietic stem cells. Development 141: 4656-4666.
de Laval, B., P. Pawlikowska, D. Barbieri, et al. 2014. Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target IEX-1. Blood 123: 509-519.
Yoshida, K., K. Kirito, H. Yongzhen, et al. 2008. Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species. Int. J. Hematol. 88: 43-51.
Kirito, K., N. Fox & K. Kaushansky. 2004. Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells. Mol. Cell. Biol. 24: 6751-6762.
Simsek, T., F. Kocabas, J. Zheng, et al. 2010. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell 7: 380-390.
Yoshihara, H., F. Arai, K. Hosokawa, et al. 2007. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 1: 685-697.
Neelis, K.J., T.P. Visser, W. Dimjati, et al. 1998. A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells. Blood 92: 1586-1597.
Haas, S., A. Trumpp & M.D. Milsom. 2018. Causes and consequences of hematopoietic stem cell heterogeneity. Cell Stem Cell 22: 627-638.
Sanjuan-Pla, A., I.C. Macaulay, C.T. Jensen, et al. 2013. Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy. Nature 502: 232-236.
Shin, J.Y., W. Hu, M. Naramura & C.Y. Park. 2014. High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias. J. Exp. Med. 211: 217-231.
Yamamoto, R., Y. Morita, J. Ooehara, et al. 2013. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell 154: 1112-1126.
Haas, S., J. Hansson, D. Klimmeck, et al. 2015. Inflammation-induced emergency megakaryopoiesis driven by hematopoietic stem cell-like megakaryocyte progenitors. Cell Stem Cell 17: 422-434.
Nakamura-Ishizu, A., T. Matsumura, P.S. Stumpf, et al. 2018. Thrombopoietin metabolically primes hematopoietic stem cells to megakaryocyte-lineage differentiation. Cell Rep. 25: 1772-1785.e6.
Suda, T., K. Takubo & G.L. Semenza. 2011. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell 9: 298-310.
Mantel, C., S. Messina-Graham & H.E. Broxmeyer. 2010. Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency: a potential strategy for reducing oxidative risk in stem cells. Cell Cycle 9: 2008-2017.
de Almeida, M.J., L.L. Luchsinger, D.J. Corrigan, et al. 2017. Dye-independent methods reveal elevated mitochondrial mass in hematopoietic stem cells. Cell Stem Cell 21: 725-729.e4.
Young, N.S. 2018. Aplastic anemia. N. Engl. J. Med. 379: 1643-1656.
Imbach, P. & M. Crowther. 2011. Thrombopoietin-receptor agonists for primary immune thrombocytopenia. N. Engl. J. Med. 365: 734-741.
Basser, R.L., E. O'Flaherty, M. Green, et al. 2002. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood 99: 2599-2602.
Kuter, D.J. 2010. Biology and chemistry of thrombopoietic agents. Semin. Hematol. 47: 243-248.
Townsley, D.M., P. Scheinberg, T. Winkler, et al. 2017. Eltrombopag added to standard immunosuppression for aplastic anemia. N. Engl. J. Med. 376: 1540-1550.
Desmond, R., D.M. Townsley, B. Dumitriu, et al. 2014. Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood 123: 1818-1825.
Kao, Y.-R., J. Chen, S.-R. Narayanagari, et al. 2018. Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag. Sci. Transl. Med. 10: eaas9563.
de Sauvage, F.J., P.E. Hass, S.D. Spencer, et al. 1994. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369: 533-538.
Columbyova, L., M. Loda & D.T. Scadden. 1995. Thrombopoietin receptor expression in human cancer cell lines and primary tissues. Cancer Res. 55: 3509-3512.
Ivanova, A., J. Wuerfel, J. Zhang, et al. 2010. Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system. BMC Dev. Biol. 10: 77.
Kuter, D.J. & R.D. Rosenberg. 1995. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85: 2720-2730.
Fielder, P.J., A.L. Gurney, E. Stefanich, et al. 1996. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87: 2154-2161.
McCarty, J.M., K.H. Sprugel, N.E. Fox, et al. 1995. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 86: 3668-3675.
de Graaf, C., M. Kauppi, T. Baldwin, et al. 2010. Regulation of hematopoietic stem cells by their mature progeny. Proc. Natl. Acad. Sci. USA 107: 21689-21694.
Nakamura-Ishizu, A. & T. Suda. 2013. Hematopoietic stem cell niche: an interplay among a repertoire of multiple functional niches. Biochim. Biophys. Acta 1830: 2404-2409.
Sungaran, R., O.T. Chisholm, B. Markovic, et al. 2000. The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. Blood 95: 3094-3101.
Hoffmann, O., O. Rung, A.-R. Im, et al. 2011. Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis. Infect. Immun. 79: 928-936.
Nakamura-Ishizu, A., K. Takubo, H. Kobayashi, et al. 2015. CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. J. Exp. Med. 212: 2133-2146.
Decker, M., J. Leslie, Q. Liu, et al. 2018. Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance. Science 360: 106-110.
Cardier, J.E. & J. Dempsey. 1998. Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: evidence of thrombopoietin as a growth factor for liver endothelial cells. Blood 91: 923-929.
Tozawa, K., Y. Ono-Uruga, M. Yazawa, et al. 2019. Megakaryocytes and platelets from a novel human adipose tissue-derived mesenchymal stem cell line. Blood 133: 633-643.