Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A.
ChIP-seq
HHV-6A
MNase-seq
RNA-seq
iciHHV-6A
latency
nucleosomes
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
02
2019
accepted:
04
06
2019
entrez:
12
7
2019
pubmed:
12
7
2019
medline:
12
7
2019
Statut:
epublish
Résumé
Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis. The HHV-6A/B genomes have been shown to be present in an integrated state in the telomeres of latently infected cells. In addition, integration of HHV-6A/B in germ cells has resulted in individuals harboring this inherited chromosomally integrated HHV-6A/B (iciHHV-6) in every cell of their body. Until now, the viral transcriptome and the epigenetic modifications that contribute to the silencing of the integrated virus genome remain elusive. In the current study, we used a patient-derived iciHHV-6A cell line to assess the global viral gene expression profile by RNA-seq, and the chromatin profiles by MNase-seq and ChIP-seq analyses. In addition, we investigated an
Identifiants
pubmed: 31293546
doi: 10.3389/fmicb.2019.01408
pmc: PMC6606781
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1408Subventions
Organisme : NIAID NIH HHS
ID : R21 AI121528
Pays : United States
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