Rhinocerebral Mucormycosis: A Prospective Analysis of an Effective Treatment Protocol.
Amphotericin B
diabetic ketoacidosis
mucormycosis
opportunistic fungi
Journal
Annals of maxillofacial surgery
ISSN: 2231-0746
Titre abrégé: Ann Maxillofac Surg
Pays: India
ID NLM: 101598423
Informations de publication
Date de publication:
Historique:
entrez:
12
7
2019
pubmed:
12
7
2019
medline:
12
7
2019
Statut:
ppublish
Résumé
The objective of this study was to prospectively analyze the effectiveness of a treatment protocol in patients diagnosed with rhinocerebral mucormycosis. This series included ten patients who reported with suspicious clinical signs of mucormycosis. The diagnosis was established by histopathology, and computed tomography imaging was used to assess the extent of spread. All patients were treated with immediate radical surgical debridement and antifungal chemotherapy with amphotericin B. Simultaneous correction of the underlying immunosuppressive condition was carried out. The primary outcome assessed was disease-free survival, and the patients were followed up for up to 6 months after discharge. In this series, the cause of immunosuppression was uncontrolled diabetes mellitus in all patients. All the patients responded to the treatment protocol and were free of the disease up to 6 months of follow-up. Mucormycosis is an invasive and potentially fatal disease. Prognosis can be improved by early recognition and prompt treatment with aggressive resection, intravenous amphotericin B, and control of the patient's underlying systemic condition.
Identifiants
pubmed: 31293952
doi: 10.4103/ams.ams_231_18
pii: AMS-9-192
pmc: PMC6585200
doi:
Types de publication
Case Reports
Langues
eng
Pagination
192-196Déclaration de conflit d'intérêts
There are no conflicts of interest.
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