Vaccinations and Infections Are Associated With Unrelated Antibody Titers: An Analysis From the German Birth Cohort Study LISA.
humoral response
immune response
infectious diseases
non-specific effects
vaccinations
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
02
2019
accepted:
04
06
2019
entrez:
12
7
2019
pubmed:
12
7
2019
medline:
12
7
2019
Statut:
epublish
Résumé
The evidence for non-specific effects (NSE) of vaccinations on all-cause morbidity and mortality among children is growing. However, our understanding of the underlying mechanisms is still limited. One hypothesis is that NSE are mediated by antibody titers. We used data of 2,123 children from the population-based birth cohort study LISA conducted in Germany to explore whether routine childhood vaccinations and the individual infection history in the first 2 years of life are associated with unrelated antibody titers. We selected 19 exposures (infections and vaccinations) and investigated their association with levels of 12 IgG antibody titers at the age of 2 years. Based on univariable analyses (ANOVA), we identified 21 crude associations between exposures and titers (
Identifiants
pubmed: 31294004
doi: 10.3389/fped.2019.00254
pmc: PMC6603196
doi:
Types de publication
Journal Article
Langues
eng
Pagination
254Références
J Clin Epidemiol. 2001 Apr;54(4):343-9
pubmed: 11297884
J Immunol. 2002 Jan 15;168(2):919-25
pubmed: 11777990
Nat Rev Immunol. 2002 Jun;2(6):417-26
pubmed: 12093008
J Epidemiol Community Health. 2003 Oct;57(10):778-83
pubmed: 14573579
Vaccine. 2005 Jan 26;23(10):1251-7
pubmed: 15652667
J Asthma. 2008 May;45(4):301-8
pubmed: 18446594
Source Code Biol Med. 2008 Oct 21;3:15
pubmed: 18939983
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20822-7
pubmed: 19075247
Cell Host Microbe. 2011 May 19;9(5):355-61
pubmed: 21575907
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012 Jun;55(6-7):864-74
pubmed: 22736169
Am J Epidemiol. 2012 Nov 1;176(9):794-802
pubmed: 23059788
Vaccine. 2013 Jun 26;31(30):3098-103
pubmed: 23583897
Trends Immunol. 2013 Sep;34(9):431-9
pubmed: 23680130
Pediatrics. 2014 Jan;133(1):e73-81
pubmed: 24379224
JAMA. 2014 Feb 26;311(8):826-35
pubmed: 24570246
Int J Epidemiol. 2014 Jun;43(3):645-53
pubmed: 24920644
Nat Immunol. 2014 Oct;15(10):895-9
pubmed: 25232810
Semin Immunol. 2014 Dec;26(6):512-7
pubmed: 25444548
Vaccine. 2015 Jan 1;33(1):237-45
pubmed: 25446818
Trans R Soc Trop Med Hyg. 2015 Jan;109(1):29-35
pubmed: 25573107
Trans R Soc Trop Med Hyg. 2015 Jan;109(1):62-9
pubmed: 25573110
Clin Infect Dis. 2015 Jun 1;60(11):1611-9
pubmed: 25725054
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671):null
pubmed: 25964459
J Leukoc Biol. 2015 Sep;98(3):347-56
pubmed: 26150551
EBioMedicine. 2016 Jun;8:341-348
pubmed: 27428443
BMJ. 2016 Oct 13;355:i5170
pubmed: 27737834
Rev Assoc Med Bras (1992). 2016 Sep;62(6):584-593
pubmed: 27849237
Trans R Soc Trop Med Hyg. 2016 Dec;110(10):570-581
pubmed: 27856947
Vaccine. 2017 Apr 11;35(16):2084-2091
pubmed: 28318766
Semin Immunol. 2018 Oct;39:35-43
pubmed: 30007489
N Engl J Med. 1979 Mar 8;300(10):530-4
pubmed: 763253
J Exp Med. 1998 Nov 2;188(9):1705-15
pubmed: 9802982