ER-Ca2+ sensor STIM regulates neuropeptides required for development under nutrient restriction in Drosophila.
Animals
Calcium
/ metabolism
Calcium Signaling
/ genetics
Drosophila Proteins
/ genetics
Drosophila melanogaster
/ genetics
Gene Expression Regulation
/ genetics
Larva
/ genetics
Neurons
/ metabolism
Neuropeptides
/ genetics
Neurosecretory Systems
Nutrients
/ metabolism
Pupa
/ genetics
RNA, Messenger
/ genetics
Stromal Interaction Molecule 1
/ genetics
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
03
2019
accepted:
28
06
2019
entrez:
12
7
2019
pubmed:
12
7
2019
medline:
27
2
2020
Statut:
epublish
Résumé
Neuroendocrine cells communicate via neuropeptides to regulate behaviour and physiology. This study examines how STIM (Stromal Interacting Molecule), an ER-Ca2+ sensor required for Store-operated Ca2+ entry, regulates neuropeptides required for Drosophila development under nutrient restriction (NR). We find two STIM-regulated peptides, Corazonin and short Neuropeptide F, to be required for NR larvae to complete development. Further, a set of secretory DLP (Dorso lateral peptidergic) neurons which co-express both peptides was identified. Partial loss of dSTIM caused peptide accumulation in the DLPs, and reduced systemic Corazonin signalling. Upon NR, larval development correlated with increased peptide levels in the DLPs, which failed to occur when dSTIM was reduced. Comparison of systemic and cellular phenotypes associated with reduced dSTIM, with other cellular perturbations, along with genetic rescue experiments, suggested that dSTIM primarily compromises neuroendocrine function by interfering with neuropeptide release. Under chronic stimulation, dSTIM also appears to regulate neuropeptide synthesis.
Identifiants
pubmed: 31295329
doi: 10.1371/journal.pone.0219719
pii: PONE-D-19-17468
pmc: PMC6622525
doi:
Substances chimiques
Crz protein, Drosophila
0
Drosophila Proteins
0
Neuropeptides
0
RNA, Messenger
0
Stim protein, Drosophila
0
Stromal Interaction Molecule 1
0
neuropeptide F
142191-57-9
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0219719Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/E/12/1/500742
Pays : India
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Neuron. 2013 Oct 2;80(1):171-83
pubmed: 24094110
Cell Tissue Res. 2008 Mar;331(3):659-73
pubmed: 18087727
J Biol Chem. 2004 Dec 3;279(49):50781-9
pubmed: 15385546
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10326-31
pubmed: 19515818
Biochem Soc Trans. 2012 Feb;40(1):279-81
pubmed: 22260705
BMC Neurosci. 2013 Dec 18;14:157
pubmed: 24350669
Physiol Rev. 2015 Oct;95(4):1383-436
pubmed: 26400989
PLoS One. 2014 Jan 28;9(1):e87062
pubmed: 24489834
Science. 2015 Feb 13;347(6223):755-60
pubmed: 25678659
PLoS One. 2009 Aug 14;4(8):e6652
pubmed: 19680544
J Neurosci. 2010 Jan 27;30(4):1301-13
pubmed: 20107057
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13972-7
pubmed: 25201989
Front Mol Neurosci. 2018 Mar 22;11:87
pubmed: 29623030
Neuron. 2012 Oct 4;76(1):82-97
pubmed: 23040808
Neuron. 2016 May 18;90(4):781-794
pubmed: 27161526
Neuron. 2014 Apr 2;82(1):79-93
pubmed: 24698269
eNeuro. 2018 Jun 18;5(3):
pubmed: 29938216
J Neurosci. 2018 Nov 21;38(47):10202-10219
pubmed: 30301757
J Neurosci. 2013 Feb 27;33(9):4044-54
pubmed: 23447613
Nat Commun. 2017 May 30;8:15563
pubmed: 28555616
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4477-81
pubmed: 21368121
J Exp Biol. 2008 Jul;211(Pt 14):2263-74
pubmed: 18587121
BMC Neurosci. 2008 Sep 19;9:90
pubmed: 18803813
Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20697-702
pubmed: 23197833
PLoS One. 2008 Mar 26;3(3):e1896
pubmed: 18365028
J Comp Neurol. 2005 Feb 21;482(4):372-85
pubmed: 15669053
PLoS Genet. 2010 May 27;6(5):e1000967
pubmed: 20523747
PLoS Genet. 2013;9(12):e1004052
pubmed: 24385933
Biochim Biophys Acta. 2013 Jun;1833(6):1294-303
pubmed: 23458835
Science. 2010 Oct 1;330(6000):101-5
pubmed: 20929812
PLoS One. 2010 Sep 20;5(9):
pubmed: 20862213
Open Biol. 2016 Nov;6(11):
pubmed: 27810969
Sci Signal. 2017 Jun 20;10(484):
pubmed: 28634208
Cell Tissue Res. 2009 May;336(2):309-23
pubmed: 19319573
J Cell Sci. 2016 Oct 15;129(20):3903-3910
pubmed: 27591258
Mol Biol Cell. 2015 Jul 1;26(13):2466-74
pubmed: 25904335
J Exp Biol. 2018 Feb 9;221(Pt 3):
pubmed: 29440283
Front Mol Neurosci. 2018 Jun 11;11:178
pubmed: 29942250
Neuron. 2012 Oct 4;76(1):98-115
pubmed: 23040809
Sci Rep. 2017 Feb 14;7:42586
pubmed: 28195208
Methods Mol Biol. 2010;615:117-27
pubmed: 20013204
Nature. 2008 Jul 10;454(7201):217-20
pubmed: 18548007
Sci Signal. 2009 Oct 20;2(93):ra67
pubmed: 19843959
Cell Mol Life Sci. 2014 Aug;71(15):2787-814
pubmed: 24442513
J Neurobiol. 2001 Nov 15;49(3):159-72
pubmed: 11745655
Sci Signal. 2014 Jun 03;7(328):ra51
pubmed: 24894994
PLoS Genet. 2013;9(10):e1003849
pubmed: 24098151
Nat Commun. 2016 Jan 12;7:10332
pubmed: 26755131
Cell Mol Life Sci. 2012 Dec;69(23):4051-66
pubmed: 22828865
Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):900-906
pubmed: 27913208
Insect Biochem Mol Biol. 2009 Nov;39(11):755-62
pubmed: 19815069
J Exp Biol. 2005 Apr;208(Pt 7):1239-46
pubmed: 15781884
Nat Genet. 2007 Jun;39(6):715-20
pubmed: 17534367
Insect Biochem Mol Biol. 2013 Sep;43(9):809-19
pubmed: 23796436
Curr Biol. 2013 Aug 5;23(15):1466-71
pubmed: 23850280
Prog Neurobiol. 2010 Sep;92(1):42-104
pubmed: 20447440
Front Mol Neurosci. 2013 Sep 18;6:29
pubmed: 24065882
Invert Neurosci. 2009 Nov;9(2):57-75
pubmed: 19756790
J Neurosci. 2015 Oct 7;35(40):13784-99
pubmed: 26446229
Neuron. 2014 May 7;82(3):635-44
pubmed: 24811382
J Endocrinol. 2006 Sep;190(3):555-70
pubmed: 17003257
J Neurochem. 2011 Aug;118(4):581-95
pubmed: 21138435
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8702-7
pubmed: 23637342
Fly (Austin). 2014;8(1):19-25
pubmed: 24406333
Development. 2017 Apr 15;144(8):1484-1489
pubmed: 28289132
Trends Endocrinol Metab. 2010 May;21(5):287-93
pubmed: 20122847
Science. 2010 Oct 1;330(6000):105-9
pubmed: 20929813