Dynamical phase transition in spike neuronal firing patterns of hippocampal cells.
Hippocampal CA1 pyramidal cells
Self-organized criticality
Spike neuronal firing
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
03 09 2019
03 09 2019
Historique:
received:
25
06
2019
accepted:
05
07
2019
pubmed:
13
7
2019
medline:
2
6
2020
entrez:
13
7
2019
Statut:
ppublish
Résumé
There is increasing evidence that the brain resides in a state of criticality. The purpose of the present work is to characterize the dynamics of individual hippocampal CA1 pyramidal cells and to investigate how it is influenced by changes in Kv7.2/7.3 (M-channel) ion channel modulation, which is known to be key in determining the neuronal excitability. We show that the resting activity of CA1 neurons exhibit random dynamics with low information content, while changes in M-channel modulation move the neuronal activity near a phase transition to richer non-trivial dynamics. We interpret these results as the basis upon which the state of self-organized criticality is built.
Identifiants
pubmed: 31296383
pii: S0006-291X(19)31346-4
doi: 10.1016/j.bbrc.2019.07.016
pii:
doi:
Substances chimiques
KCNQ2 Potassium Channel
0
KCNQ3 Potassium Channel
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1216-1221Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.