The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
02 09 2019
02 09 2019
Historique:
received:
21
11
2018
revised:
10
05
2019
accepted:
18
06
2019
pubmed:
13
7
2019
medline:
11
6
2020
entrez:
13
7
2019
Statut:
ppublish
Résumé
The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner. While most studies focus on its role in the TNF-receptor complex, we here identify a novel component in the A20-mediated decision between life and death. Loss of A20 in NK cells led to spontaneous NK cell death and severe NK cell lymphopenia. The few remaining NK cells showed an immature, hyperactivated phenotype, hallmarked by the basal release of cytokines and cytotoxic molecules. NK-A20
Identifiants
pubmed: 31296735
pii: jem.20182164
doi: 10.1084/jem.20182164
pmc: PMC6719426
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Tumor Necrosis Factor alpha-Induced Protein 3
EC 3.4.19.12
Tnfaip3 protein, mouse
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2010-2023Informations de copyright
© 2019 Vetters et al.
Références
J Exp Med. 2000 Jan 17;191(2):253-64
pubmed: 10637270
Science. 2000 Sep 29;289(5488):2350-4
pubmed: 11009421
Nat Immunol. 2002 Jun;3(6):523-8
pubmed: 12006976
J Immunol. 2002 Oct 15;169(8):4153-60
pubmed: 12370344
Blood. 2002 Nov 15;100(10):3633-8
pubmed: 12393617
Mol Cell Biol. 2004 Feb;24(4):1464-9
pubmed: 14749364
J Immunol Methods. 2004 Nov;294(1-2):15-22
pubmed: 15604012
J Immunol. 2005 Feb 1;174(3):1213-21
pubmed: 15661875
J Biol Chem. 1992 Jun 25;267(18):12424-7
pubmed: 1618749
J Immunol. 2006 Feb 1;176(3):1517-24
pubmed: 16424180
Nat Immunol. 2007 Aug;8(8):856-63
pubmed: 17618288
Mol Biol Cell. 2008 May;19(5):2092-100
pubmed: 18321988
Nat Chem Biol. 2008 May;4(5):313-21
pubmed: 18408713
Nat Immunol. 2008 May;9(5):503-10
pubmed: 18425107
Trends Biochem Sci. 2009 Mar;34(3):128-35
pubmed: 19233657
Blood. 2009 May 28;113(22):5488-96
pubmed: 19234143
Nat Rev Immunol. 2009 Aug;9(8):568-80
pubmed: 19629084
J Exp Med. 2010 Jul 5;207(7):1513-23
pubmed: 20530205
Immunity. 2010 Aug 27;33(2):181-91
pubmed: 20705491
Blood. 2011 Feb 17;117(7):2227-36
pubmed: 21088135
Blood. 2011 Feb 3;117(5):1565-73
pubmed: 21127177
Immunity. 2011 Jul 22;35(1):82-96
pubmed: 21723156
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18324-9
pubmed: 22021440
Nat Rev Immunol. 2012 Mar 22;12(4):239-52
pubmed: 22437937
Nat Cell Biol. 2013 May;15(5):481-90
pubmed: 23624402
Nature. 2013 Nov 14;503(7475):272-6
pubmed: 24089213
Nat Immunol. 2013 Dec;14(12):1219-28
pubmed: 24121838
Trends Immunol. 2014 Jan;35(1):22-31
pubmed: 24246475
Nature. 2014 May 1;509(7498):49-54
pubmed: 24670665
Nat Immunol. 2014 Aug;15(8):749-757
pubmed: 24973821
Nat Commun. 2014 Aug 14;5:4539
pubmed: 25119382
Nat Commun. 2014 Sep 30;5:5103
pubmed: 25267258
Nat Immunol. 2015 Jun;16(6):618-27
pubmed: 25939025
Autophagy. 2015;11(7):1052-62
pubmed: 26043155
Curr Opin Virol. 2016 Feb;16:15-23
pubmed: 26590692
Cell Rep. 2016 May 31;15(9):1910-9
pubmed: 27210760
Cell Death Dis. 2016 Jun 02;7(6):e2250
pubmed: 27253414
J Exp Med. 2016 Sep 19;213(10):1973-81
pubmed: 27551157
Nat Cell Biol. 2017 Jun;19(6):698-710
pubmed: 28459443
Elife. 2017 Sep 06;6:
pubmed: 28875936
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Nat Cell Biol. 2019 Jun;21(6):731-742
pubmed: 31086261
J Exp Med. 1996 Oct 1;184(4):1397-411
pubmed: 8879212
Blood. 1998 Apr 1;91(7):2272-82
pubmed: 9516125