Fibrogenesis in Chronic DSS Colitis is Not Influenced by Neutralisation of Regulatory T Cells, of Major T Helper Cytokines or Absence of IL-13.
Animals
Chronic Disease
Colitis
/ chemically induced
Crohn Disease
/ immunology
Dextran Sulfate
/ administration & dosage
Disease Models, Animal
Female
Fibrinogens, Abnormal
Fibrosis
Humans
Interleukin-13
/ genetics
Intestines
/ pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
T-Lymphocytes, Helper-Inducer
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 07 2019
11 07 2019
Historique:
received:
08
01
2019
accepted:
28
06
2019
entrez:
13
7
2019
pubmed:
13
7
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Mechanisms underlying fibrogenesis in chronic colitis are largely unknown. There is an urgent need for clinical markers and identification of targets to prevent, treat and limit intestinal fibrosis. This study investigated the contribution of major T cell cytokines and T regulatory cells (Tregs) to inflammation and fibrosis induced in a model of experimental colitis by oral intake of dextran sodium sulphate (DSS) in wild type and IL-13 knock-out C57Bl/6 mice. Inflammation and fibrosis were scored by macroscopic and histological examination and fibrosis was quantified by hydroxyproline. Numbers of Tregs and IFN-γ
Identifiants
pubmed: 31296924
doi: 10.1038/s41598-019-46472-6
pii: 10.1038/s41598-019-46472-6
pmc: PMC6624199
doi:
Substances chimiques
Fibrinogens, Abnormal
0
Interleukin-13
0
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10064Références
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