Increase of endocan, a new marker for inflammation and endothelial dysfunction, in acute kidney injury.
Acute kidney injury
endocan or endothelial cell-specific molecule 1 (ESM 1)
vitamin D
Journal
Northern clinics of Istanbul
ISSN: 2536-4553
Titre abrégé: North Clin Istanb
Pays: Turkey
ID NLM: 101684520
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
09
2017
accepted:
07
04
2018
entrez:
13
7
2019
pubmed:
13
7
2019
medline:
13
7
2019
Statut:
epublish
Résumé
In this study, the clinical relevance of the levels of serum endocan and 25-hydroxyvitamin D [25(OH)D] was investigated in patients with acute kidney injury (AKI). Endocan or the endothelial cell-specific molecule 1 is a soluble proteoglycan secreted by vascular endothelial cells. It plays a significant role in immunity, inflammation, and endothelial function. A total of 39 patients with AKI (19 females, 20 males) and 38 healthy individuals (18 females, 20 males) were included in the study. The levels of serum endocan, vitamin D, and other biochemical parameters were compared between the two groups. In the AKI group, the values of serum creatinine, endocan, parathormone, phosphorus, and uric acid were found to be higher, and the total protein, albumin, and calcium levels were lower compared to the control group. There was no difference between the two groups in terms of the serum vitamin D, magnesium, alkaline phosphatase, and gamma-glutamyl transferase. In patients with AKI, an increased endocan level is a significant marker of inflammation and endothelial injury. In addition, these patients experience vitamin D deficiency.
Identifiants
pubmed: 31297477
doi: 10.14744/nci.2018.70446
pii: NCI-6-124
pmc: PMC6593909
doi:
Types de publication
Journal Article
Langues
eng
Pagination
124-128Déclaration de conflit d'intérêts
Conflict of Interest: The authors stated that there are no conflicts of interest regarding the publication of this article.
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