Inherent control of hepatocyte proliferation after subtotal liver resection.

cyclins cytokines hepatocytes liver proliferation subtotal resection

Journal

Cell biology international
ISSN: 1095-8355
Titre abrégé: Cell Biol Int
Pays: England
ID NLM: 9307129

Informations de publication

Date de publication:
Jan 2020
Historique:
received: 07 12 2018
accepted: 09 07 2019
pubmed: 13 7 2019
medline: 13 7 2019
entrez: 13 7 2019
Statut: ppublish

Résumé

At the normal physiological conditions, hepatocytes predominantly reside in G0 phase of cell cycle; they actively proceed to G1 phase upon damage to the organ. As it was shown in experiments with restoration of liver mass in rats after subtotal hepatectomy (resection of 80% of the organ mass may be considered as a model of the 'small for size' liver syndrome), the growth inhibition is due to prolonged arrest of hepatocyte proliferation, molecular mechanisms of which remain understudied. In a rat model of liver regeneration after surgical removal of 80% of its mass, we observe a delayed onset of hepatocyte proliferation: Ki67

Identifiants

DOI: 10.1002/cbin.11203 PMID: 31297922
pubmed: 31297922
doi: 10.1002/cbin.11203
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

80-88

Subventions

Organisme : This research was supported by Russian Science Foundation
ID : Project no. 17-15-01419

Informations de copyright

© 2019 International Federation for Cell Biology.

Auteurs

Andrey Elchaninov (A)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation.
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation.

Timur Fatkhudinov (T)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation.
Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation.

Andrey Makarov (A)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation.
Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 1 Ostrovitianov Street, Moscow, 117997, Russian Federation.

Iva Vorobieva (I)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation.

Anastasia Lokhonina (A)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation.

Natalia Usman (N)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation.

Evgeniya Kananykhina (E)

Research Institute of Human Morphology, 3 Tsurupa Street, Moscow, 117418, Russian Federation.

Polina Vishnyakova (P)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation.

Maria Nikitina (M)

Research Institute of Human Morphology, 3 Tsurupa Street, Moscow, 117418, Russian Federation.

Dmitry Goldshtein (D)

Research Center of Medical Genetics, 1 Moscvorechie, Moscow, 115478, Russian Federation.

Galina Bolshakova (G)

Research Institute of Human Morphology, 3 Tsurupa Street, Moscow, 117418, Russian Federation.

Valeria Glinkina (V)

Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 1 Ostrovitianov Street, Moscow, 117997, Russian Federation.

Gennady Sukhikh (G)

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow, 117997, Russian Federation.

Classifications MeSH