Topical hydrogels with escin β-sitosterol phytosome and escin: Formulation development and in vivo assessment of antihyperalgesic activity.
Wistar rats
analgesia
escin
hydrogel
inflammation
pain
Journal
Drug development research
ISSN: 1098-2299
Titre abrégé: Drug Dev Res
Pays: United States
ID NLM: 8204468
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
18
03
2019
revised:
10
06
2019
accepted:
30
06
2019
pubmed:
13
7
2019
medline:
21
4
2020
entrez:
13
7
2019
Statut:
ppublish
Résumé
The physicochemical properties, stability, in vivo antihyperalgesic activity, and skin irritation potential of the carbomer hydrogels with the new chemical entity escin β-sitosterol (ES) phytosome were characterized and compared with those containing escin. Physicochemical characterization of the hydrogels (performed 48 hr after preparation) included organoleptic examination, pH measurement, light microscopy, differential scanning calorimetry analysis and rheological tests. The obtained results showed that increasing concentration of the active substances within 1-5% affected the appearance (color and transparency) of the hydrogels, their pH, consistency, and rheological behavior. Unlike acidic escin, which was dissolved in the liquid phase of the pseudoplastic hydrogels E1-E5 and reduced their maximal apparent viscosity (η
Substances chimiques
Hydrogels
0
Sitosterols
0
gamma-sitosterol
5LI01C78DD
Escin
6805-41-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
921-932Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
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