Heme Oxygenase-1 dictates innate - adaptive immune phenotype in human liver transplantation.
Journal
Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
03
05
2019
revised:
03
07
2019
accepted:
08
07
2019
pubmed:
13
7
2019
medline:
7
3
2020
entrez:
13
7
2019
Statut:
ppublish
Résumé
Liver transplantation (LT) has become the standard of care for patients with end-stage liver disease and those with hepatic malignancies, while adaptive immune-dominated graft rejection remains a major challenge. Despite potent anti-inflammatory and cytoprotective functions of heme oxygenase-1 (HO-1) overexpression upon innate immune-driven hepatic ischemia reperfusion injury, its role in adaptive immune cell-driven responses remains to be elucidated. We analyzed human biopsies from LT recipients (n = 55) to determine putative association between HO-1 levels and adaptive/co-stimulatory gene expression programs in LT. HO-1 expression negatively correlated with innate (CD68, Cathepsin G, TLR4, CXCL10), adaptive (CD4, CD8, IL17) and co-stimulatory (CD28, CD80, CD86) molecules at the graft site. LT recipients with high HO-1 expression showed a trend towards improved overall survival. By demonstrating the association between graft HO-1 levels and adaptive/co-stimulatory gene programs, our study provides important insights to the role of HO-1 signaling in LT patients.
Identifiants
pubmed: 31299184
pii: S0003-9861(19)30276-0
doi: 10.1016/j.abb.2019.07.007
pmc: PMC6688971
mid: NIHMS1535171
pii:
doi:
Substances chimiques
Heme Oxygenase-1
EC 1.14.14.18
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
162-166Subventions
Organisme : NIAID NIH HHS
ID : P01 AI120944
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK062357
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102110
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107533
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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