Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960's.
Breast cancer
DDT
Exposome
Gene environment interaction
Hierarchical community network
MWAS
Metabolic phenotype
Metabolomics
Mixed exposures
Multi-omics integration
PCB
PFAS
Variance analysis
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
31
10
2018
revised:
20
06
2019
accepted:
28
06
2019
pubmed:
13
7
2019
medline:
29
4
2021
entrez:
13
7
2019
Statut:
ppublish
Résumé
Even though the majority of population studies in environmental health focus on a single factor, environmental exposure in the real world is a mixture of many chemicals. The concept of "exposome" leads to an intellectual framework of measuring many exposures in humans, and the emerging metabolomics technology offers a means to read out both the biological activity and environmental impact in the same dataset. How to integrate exposome and metabolome in data analysis is still challenging. Here, we employ a hierarchical community network to investigate the global associations between the metabolome and mixed exposures including DDTs, PFASs and PCBs, in a women cohort with sera collected in California in the 1960s. Strikingly, this analysis revealed that the metabolite communities associated with the exposures were non-specific and shared among exposures. This suggests that a small number of metabolic phenotypes may account for the response to a large class of environmental chemicals.
Identifiants
pubmed: 31299210
pii: S0890-6238(18)30603-8
doi: 10.1016/j.reprotox.2019.06.013
pmc: PMC6949431
mid: NIHMS1535624
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-65Subventions
Organisme : NIEHS NIH HHS
ID : U2C ES030163
Pays : United States
Organisme : NIAID NIH HHS
ID : UH2 AI132345
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA235493
Pays : United States
Organisme : NIH HHS
ID : S10 OD018006
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES019776
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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