Inactivated recombinant Escherichia coli as a candidate vaccine against Clostridium perfringens alpha toxin in sheep.
Animals
Antibodies, Bacterial
/ blood
Antitoxins
/ blood
Bacterial Toxins
/ genetics
Bacterial Vaccines
/ administration & dosage
Calcium-Binding Proteins
/ genetics
Clostridium Infections
/ prevention & control
Drug Carriers
Escherichia coli
/ genetics
Rabbits
Recombinant Proteins
/ genetics
Sheep
Type C Phospholipases
/ genetics
Vaccines, Synthetic
/ administration & dosage
Alpha-toxin
Clostridiosis
Enterotoxaemia
Gas gangrene
Recombinant bacterin
Journal
Anaerobe
ISSN: 1095-8274
Titre abrégé: Anaerobe
Pays: England
ID NLM: 9505216
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
29
01
2019
revised:
20
05
2019
accepted:
04
07
2019
pubmed:
13
7
2019
medline:
21
1
2020
entrez:
13
7
2019
Statut:
ppublish
Résumé
Clostridium perfringens type A is the causative agent of gas gangrene and gastroenteric ("yellow lamb disease") disease in ruminants, with C. perfringens alpha toxin (CPA) being the main virulence factor in the pathogenesis of these illnesses. In the present study, we have developed recombinant Escherichia coli bacteria expressing rCPA and used it to vaccinate rabbits and sheep. Doses of up to 200 μg of rCPA used for inoculation, induced 13.82 IU.mL
Identifiants
pubmed: 31299397
pii: S1075-9964(19)30119-2
doi: 10.1016/j.anaerobe.2019.07.002
pii:
doi:
Substances chimiques
Antibodies, Bacterial
0
Antitoxins
0
Bacterial Toxins
0
Bacterial Vaccines
0
Calcium-Binding Proteins
0
Drug Carriers
0
Recombinant Proteins
0
Vaccines, Synthetic
0
Type C Phospholipases
EC 3.1.4.-
alpha toxin, Clostridium perfringens
EC 3.1.4.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
163-166Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.