Sex differences in brain activation patterns with mental stress in patients with coronary artery disease.
Journal
Biology of sex differences
ISSN: 2042-6410
Titre abrégé: Biol Sex Differ
Pays: England
ID NLM: 101548963
Informations de publication
Date de publication:
12 07 2019
12 07 2019
Historique:
received:
26
02
2019
accepted:
27
06
2019
entrez:
14
7
2019
pubmed:
14
7
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Stress is an important contributor to myocardial ischemia and the progression of coronary artery disease (CAD), and women are more susceptible than men to these effects. Little is known, however, about the neural basis of these sex differences. We investigated sex differences in neural correlates of mental stress in a sample of 53 female and 112 male participants (N = 165) with CAD, with and without mental stress-induced myocardial ischemia (MSI), during exposure to mental arithmetic tasks and public speaking stress tasks using high-resolution positron emission tomography (HR-PET) and radiolabeled water imaging of the brain. Women compared to men had significantly greater activation with stress in the right frontal (BA 9, 44), right parietal lobe (Area 3, 6, 40), right posterior cingulate gyrus (BA 31), bilateral cerebellum, and left temporal/fusiform gyrus (BA 37) and greater deactivation in bilateral anterior cingulate gyrus (BA 24, 32), bilateral medial frontal gyrus (BA 6, 8, 9, 10), right parahippocampal gyrus, and right middle temporal gyrus (BA 21). Women with MSI (but not those without MSI) showed significantly greater activation than men in the right posterior cingulate gyrus (BA 31) and greater deactivation in several frontal and temporal lobe areas. Men and women with CAD show differences in responses to stress in brain limbic areas that regulate emotion, and these functional responses differ by MSI status. Our results suggest that the cingulate gyrus may be involved in sex differences in MSI.
Sections du résumé
BACKGROUND
Stress is an important contributor to myocardial ischemia and the progression of coronary artery disease (CAD), and women are more susceptible than men to these effects. Little is known, however, about the neural basis of these sex differences.
METHODS
We investigated sex differences in neural correlates of mental stress in a sample of 53 female and 112 male participants (N = 165) with CAD, with and without mental stress-induced myocardial ischemia (MSI), during exposure to mental arithmetic tasks and public speaking stress tasks using high-resolution positron emission tomography (HR-PET) and radiolabeled water imaging of the brain.
RESULTS
Women compared to men had significantly greater activation with stress in the right frontal (BA 9, 44), right parietal lobe (Area 3, 6, 40), right posterior cingulate gyrus (BA 31), bilateral cerebellum, and left temporal/fusiform gyrus (BA 37) and greater deactivation in bilateral anterior cingulate gyrus (BA 24, 32), bilateral medial frontal gyrus (BA 6, 8, 9, 10), right parahippocampal gyrus, and right middle temporal gyrus (BA 21). Women with MSI (but not those without MSI) showed significantly greater activation than men in the right posterior cingulate gyrus (BA 31) and greater deactivation in several frontal and temporal lobe areas.
CONCLUSION
Men and women with CAD show differences in responses to stress in brain limbic areas that regulate emotion, and these functional responses differ by MSI status. Our results suggest that the cingulate gyrus may be involved in sex differences in MSI.
Identifiants
pubmed: 31300046
doi: 10.1186/s13293-019-0248-4
pii: 10.1186/s13293-019-0248-4
pmc: PMC6626382
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
35Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL109413
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH056120
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG026255
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL127251
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL077506
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL073824
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL068630
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL101398
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR016917
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH067547
Pays : United States
Organisme : CSRD VA
ID : I01 CX000687
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125246
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH076955
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL088726
Pays : United States
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