Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners.
Dpr and DIP proteins
Drosophila visual system
cell recognition molecules
synapse formation
synaptic specificity
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
04 09 2019
04 09 2019
Historique:
received:
24
08
2018
revised:
19
04
2019
accepted:
11
06
2019
pubmed:
14
7
2019
medline:
28
3
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
The ability of neurons to identify correct synaptic partners is fundamental to the proper assembly and function of neural circuits. Relative to other steps in circuit formation such as axon guidance, our knowledge of how synaptic partner selection is regulated is severely limited. Drosophila Dpr and DIP immunoglobulin superfamily (IgSF) cell-surface proteins bind heterophilically and are expressed in a complementary manner between synaptic partners in the visual system. Here, we show that in the lamina, DIP mis-expression is sufficient to promote synapse formation with Dpr-expressing neurons and that disrupting DIP function results in ectopic synapse formation. These findings indicate that DIP proteins promote synapses to form between specific cell types and that in their absence, neurons synapse with alternative partners. We propose that neurons have the capacity to synapse with a broad range of cell types and that synaptic specificity is achieved by establishing a preference for specific partners.
Identifiants
pubmed: 31300277
pii: S0896-6273(19)30556-2
doi: 10.1016/j.neuron.2019.06.006
pmc: PMC6728174
mid: NIHMS1532555
pii:
doi:
Substances chimiques
Drosophila Proteins
0
Immunoglobulins
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
865-877.e7Subventions
Organisme : NINDS NIH HHS
ID : K01 NS094545
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103905
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110713
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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